Table 5.

Diagnostic accuracy of the biomarkers for average and high-risk women

Cases vs healthy controls
Cases vs benign controls
AUCSensitivity at 95% specificitySensitivity at 98% specificityAUCSensitivity at 95% specificitySensitivity at 98% specificity
CA125
    Average-risk0.93979.4178.430.88058.8249.02
    High-risk0.93982.9378.050.83563.4160.98
    AUC differences P*0.980.45
Mesothdin
    Average-risk0.79353.9244.120.78943.1437.25
    High-risk0.73439.0231.710.72734.1529.27
    AUC differences P*0.360.42
HE4
    Average-risk0.92880.3968.630.88361.7657.84
    High-risk0.93187.8082.930.90275.6170.73
    AUC differences P*0.940.69
  • * The AUC differences between the average- and high-risk women were compared for each biomarker using the nonparametric methods developed by DeLong (29).