Table 4.

Marker levels for the controls and cases by risk status

Average-risk
High-risk
P*
nMean (SE)nMean (SE)
Healthy controls150294
    CA1250 (1.0)−0.8 (0.8)<0.001
    Mesothelin0 (1.0)0.1 (1.0)0.63
    HE40 (1.0)−0.2 (1.0)0.10
Benign controls11014
    CA1250.7 (1.4)0.5 (1.1)0.67
    Mesothelin0.02 (1.2)0.1 (1.1)0.79
    HE40.4 (1.3)0.3 (1.3)0.95
CASES10241
    CA1254.2 (2.6)3.6 (2.6)0.17
    Mesothelin2.6 (2.8)2.2 (2.8)0.38
    HE45.2 (3.9)5.5 (3.6)0.63
Cases (by histology)
Clear cell82
    CA1251.8 (2.0)0.6 (0.1)0.15
    Mesothelin0.3 (1.1)−1.0 (0.5)0.09
    HE40.7 (1.3)2.1 (0.8)0.17
Endometrioid104
    CA1254.7 (3.1)3.5 (4.2)0.61
    Mesothelin1.2 (2.2)0.9 (3.2)0.85
    HE44.9 (3.4)5.7 (4.8)0.77
Mucinous62
    CA1253.0 (1.9)3.4 (1.5)0.80
    Mesothelin−0.2 (0.6)1.8 (0.2)<0.001
    HE41.6 (1.4)6.7 (0.8)0.006
Serous6624
    CA1254.8 (2.4)4.4 (2.1)0.50
    Mesothelin3.7 (2.6)2.8 (2.6)0.16
    HE46.4 (3.8)6.3 (3.5)0.95
Other9
    CA1253.1 (2.9)2.1 (2.8)0.42
    Mesothelin1.0 (2.5)1.9 (3.3)0.50
    HE43.8 (3.5)3.9 (3.7)0.93
Cases (by stage)
Stage 1296
    CA1252.5 (2.6)2.8 (2.5)0.85
    Mesothelin0.4 (1.4)0.2 (1.7)0.82
    HE41.7 (2.0)3.9 (3.2)0.15
Stage 273
    CA1253.4 (2.3)2.8 (2.4)0.73
    Mesothelin1.0 (1.3)2.3 (3.7)0.62
    HE45.3 (3.0)6.2 (2.1)0.63
Stage 35322
    CA1255.3 (2.1)4.4 (2.2)0.12
    Mesothelin3.8 (2.7)3.0 (2.9)0.26
    HE47.1 (3.5)6.8 (3.1)0.72
Stage 4104
    CA1254.6 (2.8)5.8 (1.6)0.38
    Mesothelin3.4 (3.0)3.2 (2.6)0.88
    HE44.5 (3.3)7.9 (2.1)0.05
  • NOTE: The marker values have been log transformed and standardized to a mean of 0 and an SD of 1 in the average risk controls.

  • * P values were obtained from the Student's t test.