Table 1.

Criteria used to classify women as high-risk for ovarian cancer

The woman's family contained at least two ovarian or breast cancer cases among the subject or her first or second-degree relatives. This condition was satisfied by multiple primary cancers in the same person. In situations where breast cancer was used to meet this criterion, at least one breast cancer must have been diagnosed before menopause. If menopausal status was unknown, women under the age of 50 y were considered to be premenopausal; or
The woman was of Ashkenazi Jewish ethnicity with one first-degree relative or two second-degree relatives with breast or ovarian cancer, or the woman was of Ashkenazi ancestry and had a personal history of breast cancer. As explained above, in situations where breast cancer was used to meet this criterion, at least one breast cancer must have been diagnosed before menopause; or
The probability of carrying a BRCA I or BRCA II mutation given family pedigree of breast and ovarian cancer exceeded 20%. This was determined by the BRCAPRO 95% posterior probability interval. This criterion included women who tested positive for a BRCA I or BRCA II mutation and women who had a first- or second-degree relative with a BRCA I or BRCA II mutation.