Table 4.

The risk of breast cancer associated with genetic variation modeled as CYP1B1*2-GSTP1 gene-gene interactions

Case n (%)*Control n (%)*No. high-risk genotypes
OR (95% CI)
GSTP1CYP1B1*2
79 (9.0)108 (12.6)001.0 (reference)
10 (1.1)8 (0.9)011.81 (0.64-5.07)
714 (81.4)696 (81.5)101.53 (0.99-2.35)
74 (8.4)42 (4.9)112.78 (1.46-5.32)
Pint = 0.36
  • * Some percentages do not sum to 100% due to rounding.

  • High-risk genotypes as determined in the single-gene analyses: A/A and A/G for GSTP1 and T/T for CYP1B1.

  • Adjusted for age and year of diagnosis (reference date for controls).