Table 2.

The risk of breast cancer associated with genetic variation as investigated in single-gene models

GeneGenotypeCase n (%)Control n (%)OR (95% CI)
COMTG/G (Val/Val)224 (25.1)211 (24.0)1.0 (reference)
G/A (Val/Met)427 (48.0)431 (49.1)0.94 (0.74-1.18)
A/A (Met/Met)240 (26.9)236 (26.9)0.97 (0.75-1.26)
CYP1B1*2G/G (Ala/Ala)452 (51.5)454 (53.0)1.0 (reference)
G/T (Ala/Ser)341 (38.8)353 (41.2)0.99 (0.81-1.20)
T/T (Ser/Ser)84 (9.6)50 (5.8)1.69 (1.17-2.46)
CYP1B1*3C/C (Leu/Leu)289 (32.6)271 (31.0)1.0 (reference)
C/G (Leu/Val)409 (46.2)427 (48.9)0.90 (0.73-1.11)
G/G (Val/Val)188 (21.2)176 (20.1)1.00 (0.77-1.30)
GSTP1A/A (Ile/Ile)382 (42.9)366 (41.8)1.0 (reference)
A/G (Ile/Val)417 (46.8)390 (44.6)1.04 (0.85-1.27)
G/G (Val/Val)92 (10.3)119 (13.6)0.73 (0.54-0.99)
GSTM1Present421 (47.4)415 (47.4)1.0 (reference)
Null467 (52.5)460 (52.6)1.00 (0.83-1.21)
GSTT1Present744 (83.5)738 (84.2)1.0 (reference)
Null147 (16.5)139 (15.8)1.04 (0.81-1.34)
  • NOTE: OR adjusted for age and year of diagnosis (reference date for controls).