Table 2.

Haplotypes of CYP1B1 polymorphisms and risk of invasive breast cancer

CYP1B1 haplotype*Invasive breast cancer
Frequency (%)
OR (95% CI)
Cases (n = 1655)Controls (n = 1470)
CCCAACTA23.423.41.00 (Reference)
CTCAACTG17.719.70.91 (0.78-1.07)
CCCAGCCG18.318.11.03 (0.88-1.21)
TCCCATCG17.517.21.01 (0.86-1.19)
TCCAACCG8.27.81.08 (0.88-1.33)
CCCCATTG3.83.91.02 (0.77-1.35)
CCTAACTA4.23.11.40 (1.05-1.87)
CTCAATTG1.80.92.00 (1.23-3.27)
Rare haplotypes5.15.90.86 (0.66-1.13)
Pglobal = 0.015
  • * Polymorphic bases include rs163077, rs163086, rs9341266, rs162562, rs1800440, rs162557, rs162556, and rs10175368.

  • ORs based on an additive effect model with adjustment for reference age (categorical) and state of residence.

  • Haplotypes with <1% frequency.