Table 5.

Haplotype analysis of MMS19L and risk for pancreatic cancer

HaplotypeMMS19L SNP
PSim PHaplotype frequencies
Unadjusted
Adjusted*
1
2
3
4
5
6
7
A>GA>TG>CG>AA>GA>GA>GOverallControlsCasesOR (95% CI)OR (95% CI)
A(referent)ATGGAAA0.0050.0050.4290.4080.4491.001.00
BAACGAGA0.0050.0040.2790.2980.2600.80 (0.69-0.92)0.85 (0.73-0.99)
CGAGGGGC0.5060.5320.1350.1310.1380.96 (0.80-1.15)0.93 (0.77-1.13)
DGAGGGAA0.4000.3950.0840.0800.0871.00 (0.79-1.25)1.03 (0.82-1.31)
EAAGAGGC0.0460.0590.0420.0480.0360.69 (0.51-0.93)0.65 (0.47-0.90)
FAAGGAGC0.2240.2210.0170.0200.0150.70 (0.44-1.10)0.66 (0.41-1.08)
Rare-------0.0110.0110.0110.93 (0.49-1.77)0.94 (0.47-1.88)
  • NOTE: Global Test [stat = 16.098, df = 6, P = 0.0132, simulated (S = 1000) P = 0.012].

  • * Adjusted for age, sex, ever/never smoking, diabetes, first-degree relative with pancreatic cancer, and BMI.

  • SNP 1 is rs29001322, 2 is rs2236575, 3 is rs872106, 4 is rs3381, 5 is rs4917772, 6 is rs2211243, 7 is rs7915501.