Haplotype analysis of MMS19L and risk for pancreatic cancer
| Haplotype | MMS19L SNP | P | Sim P | Haplotype frequencies | Unadjusted | Adjusted* | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1† | 2 | 3 | 4 | 5 | 6 | 7 | ||||||||||||||||
| A>G | A>T | G>C | G>A | A>G | A>G | A>G | Overall | Controls | Cases | OR (95% CI) | OR (95% CI) | |||||||||||
| A(referent) | A | T | G | G | A | A | A | 0.005 | 0.005 | 0.429 | 0.408 | 0.449 | 1.00 | 1.00 | ||||||||
| B | A | A | C | G | A | G | A | 0.005 | 0.004 | 0.279 | 0.298 | 0.260 | 0.80 (0.69-0.92) | 0.85 (0.73-0.99) | ||||||||
| C | G | A | G | G | G | G | C | 0.506 | 0.532 | 0.135 | 0.131 | 0.138 | 0.96 (0.80-1.15) | 0.93 (0.77-1.13) | ||||||||
| D | G | A | G | G | G | A | A | 0.400 | 0.395 | 0.084 | 0.080 | 0.087 | 1.00 (0.79-1.25) | 1.03 (0.82-1.31) | ||||||||
| E | A | A | G | A | G | G | C | 0.046 | 0.059 | 0.042 | 0.048 | 0.036 | 0.69 (0.51-0.93) | 0.65 (0.47-0.90) | ||||||||
| F | A | A | G | G | A | G | C | 0.224 | 0.221 | 0.017 | 0.020 | 0.015 | 0.70 (0.44-1.10) | 0.66 (0.41-1.08) | ||||||||
| Rare | - | - | - | - | - | - | - | 0.011 | 0.011 | 0.011 | 0.93 (0.49-1.77) | 0.94 (0.47-1.88) | ||||||||||
NOTE: Global Test [stat = 16.098, df = 6, P = 0.0132, simulated (S = 1000) P = 0.012].
↵* Adjusted for age, sex, ever/never smoking, diabetes, first-degree relative with pancreatic cancer, and BMI.
↵† SNP 1 is rs29001322, 2 is rs2236575, 3 is rs872106, 4 is rs3381, 5 is rs4917772, 6 is rs2211243, 7 is rs7915501.