Table 4.

Pancreatic cancer risk analyses for associated MMS19L SNPs in selected subgroups

Group (ncases/ncontrols)*rs2236575
rs872106
rs2211243
A>TG>CA>G
Male (n = 668/557)1.1 (0.94-1.287)0.961 (0.805-1.147)0.875 (0.748-1.024)
Female (n = 475/540)1.301 (1.086-1.557)0.712 (0.588-0.861)0.787 (0.662-0.935)
Never smokers (n = 455/592)1.156 (0.968-1.38)0.852 (0.704-1.032)0.88 (0.741-1.045)
Ever smokers (n = 682/505)1.209 (1.029-1.421)0.839 (0.703-1.002)0.795 (0.677-0.933)
Pack-years <20 (n = 186/284)1.202 (0.924-1.65)0.725 (0.543-0.968)0.744 (0.573-0.965)
Pack-years 20-40 (n = 149/119)1.187 (0.853-1.51)1.055 (0.727-1.531)0.861 (0.622-1.191)
Pack-years >40 (n = 135/77)1.239 (0.834-1.84)0.805 (0.516-1.256)0.723 (0.488, 1.07)
Current smokers (n = 148/41)0.679 (0.403-1.143)1.175 (0.646-2.138)1.026 (0.613-1.72)
Former smokers quitting 1-15 y prior to diagnosis/enrollment (n-447/134)0.965 (0.718-1.298)0.882 (0.642-1.212)0.947 (0.708-1.265)
Former smokers quitting >15 y prior to diagnosis/enrollment (n = 228/365)1.425 (1.131-1.797)0.7 (0.535-0.916)0.622 (0.492-0.787)
Age <60 y (n = 329/297)1.064 (0.847-1.338)0.968 (0.764-1.226)0.891 (0.714, 1.111)
Age =60 y (n = 814/800)1.245 (1.085-1.429)0.785 (0.673-0.915)0.805 (0.702-0.923)
Local (MN,WI,IA) (n = 579/748)1.113 (0.953-1.299)0.875 (0.738-1.036)0.854 (0.733-0.996)
Nonlocal (n = 564/349)1.263 (1.045-1.527)0.799 (0.65-0.982)0.825 (0.685-0.993)
BMI <30 kg/m2(n = 769/858)1.211 (1.055-1.389)0.822 (0.707-0.955)0.812 (0.71-0.929)
BMI >30 kg/m2(n = 374/239)1.162 (0.916-1.472)0.858 (0.662-1.112)0.862 (0.682-1.901)
  • * All analyses are unadjusted OR (95% CI) using an additive model. The ORs correspond to a unit increase in the number of variant alleles under the additive model.

  • Defined as either current smoking at diagnosis/enrollment or quit within the preceding 1 y.