Table 3.

Association studies of SNPs in MMS19L for pancreatic cancer risk

Group (Ncases/Ncontrols)rs29001322
rs2236575
rs872106
rs3381
rs4917772
rs2211243
rs7915501
A>GA>TG>CG>AA>GA>GA>C
Genotype frequencies cases/controls1,142/1,0961,138/1,0961,143/1,0951,143/1,0971,143/1,0971,139/1,0911,119/1,075
    Major/major675/673340/384628/5501,058/994611/588342/269719/683
    Major/minor414/379559/521433/43685/99458/441543/532361/346
    Minor/minor53/44239/19182/1090/474/68254/29039/46
Hardy-Weinberg equilibrium0.300.530.100.320.220.420.79
OR (95% CI) for pancreatic cancer risk
Overall (codominant)* major/minor vs. major/major1.093 (0.907-1.316)1.184 (0.97-1.446)0.914 (0.759-1.101)0.749 (0.542-1.035)0.98 (0.816-1.177)0.792 (0.641-0.978)0.921 (0.76-1.117)
Minor/minor vs. major/major1.072 (0.691-1.661)1.34 (1.039-1.727)0.767 (0.555-1.059)-0.963 (0.666-1.393)0.711 (0.557-0.908)0.751 (0.473-1.194)
Overall (additive)*1.099 (0.949-1.273)1.19 (1.055-1.343)0.841 (0.738-0.959)0.719 (0.534-0.969)1.008 (0.878-1.157)0.829 (0.737-0.933)0.941 (0.809-1.095)
Overall (dominant)*1.121 (0.943-1.332)1.287 (1.074-1.543)0.836 (0.706-0.99)0.74 (0.545-1.005)1.009 (0.852-1.196)0.769 (0.636-0.931)0.952 (0.797-1.137)
Overall (recessive)*1.107 (0.729-1.682)1.223 (0.985-1.518)0.702 (0.517-0.953)-1.013 (0.716-1.433)0.785 (0.645-0.957)0.808 (0.52-1.256)
  • Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.

  • * Adjusted for age, sex, ever/never smoking, diabetes, 1st degree relative with pancreatic cancer, and BMI.