Table 2.

Results of principal components analysis of nucleotide excision repair genes and pancreatic cancer risk

Gene name	# SNPs	Chromosome location	Unadjusted P*	Adjusted P^†	Principal components^‡
ERCC1	4	19q13.32	0.2728	0.6705	3
ERCC2/XPD	10	19q13.32	0.3708	0.4229	5
ERCC3/XPB	7	2q14.3	0.4665	0.4154	4
ERCC4/XPF	4	16p13.12	0.7057	0.7866	3
ERCC5/XPG	14	13q33.1	0.5921	0.7214	5
ERCC6/CSB	12	10q11.23	0.4752	0.4524	4
ERCC8/CSA	11	5q12.1	0.2593	0.2623	4
XPA	7	9q22.33	0.1723	0.4038	5
XPC	9	3p25.1	0.3522	0.1697	5
RPA1	17	17p13.3	0.3186	0.3036	6
RPA2	7	1p35.3	0.2553	0.4069	3
RPA3	40	7p21.3	0.3151	0.3100	8
GTF2H1	7	11p15.1	0.2258	0.4933	3
GTF2H2	0	5q13.2	-	-	-
GTF2H3	3	12q24.31	0.7830	0.8007	2
GTF2H4	4	6p21.33	0.0515	0.0911	4
LIG1	14	19p13.2	0.2061	0.4489	3
RAD23A	1	19p13.13	0.4118	0.4864	1
RAD23B	20	9q31.2	0.9291	0.8288	6
CETN2	2	Xq28	0.9524	0.8358	2
CDK7	2	5q13.2	0.1080	0.1287	2
CCNH	2	5q14.3	0.3447	0.1898	2
MNAT1	15	14q23.1	0.1219	0.1316	5
XAB2 (HCNP)	6	19p13.2	0.7352	0.6284	3
DDB1	3	11q12.2	0.8722	0.9655	3
DDB2	8	11p11.2	0.4991	0.4876	5
MMS19L	7	10q24.1	0.0058	0.0230	3
Total
27	236

↵* Likelihood ratio test.
↵† Likelihood ratio test adjusted for age, sex, ever/never smoking, BMI, diabetes, first-degree family history of pancreatic cancer.
↵‡ Number of principal components needed to meet 90% explained variance criteria.