Table 2.

Results of principal components analysis of nucleotide excision repair genes and pancreatic cancer risk

Gene name# SNPsChromosome locationUnadjusted P*Adjusted PPrincipal components
ERCC1419q13.320.27280.67053
ERCC2/XPD1019q13.320.37080.42295
ERCC3/XPB72q14.30.46650.41544
ERCC4/XPF416p13.120.70570.78663
ERCC5/XPG1413q33.10.59210.72145
ERCC6/CSB1210q11.230.47520.45244
ERCC8/CSA115q12.10.25930.26234
XPA79q22.330.17230.40385
XPC93p25.10.35220.16975
RPA11717p13.30.31860.30366
RPA271p35.30.25530.40693
RPA3407p21.30.31510.31008
GTF2H1711p15.10.22580.49333
GTF2H205q13.2---
GTF2H3312q24.310.78300.80072
GTF2H446p21.330.05150.09114
LIG11419p13.20.20610.44893
RAD23A119p13.130.41180.48641
RAD23B209q31.20.92910.82886
CETN22Xq280.95240.83582
CDK725q13.20.10800.12872
CCNH25q14.30.34470.18982
MNAT11514q23.10.12190.13165
XAB2 (HCNP)619p13.20.73520.62843
DDB1311q12.20.87220.96553
DDB2811p11.20.49910.48765
MMS19L710q24.10.00580.02303
Total
27236
  • * Likelihood ratio test.

  • Likelihood ratio test adjusted for age, sex, ever/never smoking, BMI, diabetes, first-degree family history of pancreatic cancer.

  • Number of principal components needed to meet 90% explained variance criteria.