Table 2.

Associations with prostate cancer by disease subgroup and case-only testing

SNPChr./Nearest GeneAllele testedOR (95% CI)*/Risk allele frequency
Phet
Advanced cases (961 ca/2,359 co)Nonadvanced cases (1,600 ca/2,359 co)
rs7210482p15A1.00 (0.82-1.21)1.11 (0.94-1.30)0.33
EHBP10.090.09
rs26607533p12.1T1.15 (1.01-1.30)1.06 (0.96-1.19)0.26
0.260.26
rs93645546q25.3T1.06 (0.93-1.21)1.12 (0.99-1.25)0.53
SLC22A30.220.22
rs104865677p15.2G1.13 (0.99-1.29)1.31 (1.17-1.46)0.088
JAZF10.470.47
rs64656577q21.3C0.95 (0.83-1.08)1.04 (0.93-1.17)0.17
LMTK20.750.75
rs1099399410q11.23T1.07 (0.96-1.20)1.16 (1.06-1.27)0.19
MSMB0.470.47
rs1276901910q26.13G1.16 (1.00-1.36)1.08 (0.94-1.23)0.36
CTBP20.150.15
rs793134211q13.2G1.17 (1.04-1.32)1.10 (1.00-1.22)0.37
0.450.45
rs1164974317q12G1.14 (0.99-1.32)1.10 (0.98-1.25)0.69
HNF1B0.800.80
rs443079617q12A1.16 (1.03-1.30)1.15 (1.05-1.27)0.88
HNF1B0.530.53
rs185996217q24.3G1.00 (0.89-1.12)1.07 (0.97-1.18)0.27
0.420.42
rs273583919q13G1.03 (0.91-1.17)1.09 (0.98-1.21)0.33
KLK2/30.700.70
rs5945572Xp11.22A1.27 (1.04-1.55)1.31 (1.11-1.54)0.84
NUDT10/110.190.19
  • * ORs were adjusted for age (quintiles)-ethnicity strata and genome-wide European ancestry (African Americans, Latinos and Native Hawaiians).

  • Phet = P value for heterogeneity (advanced versus nonadvanced).