Table 1.

Frequencies of risk alleles and associations with prostate cancer risk in the MEC

SNPChr./Nearest GeneAllele testedOR (95% CI)*/Risk Allele Frequency
Pooled (2,768 ca/2,359 co)PPhet
African Americans (860 ca/575 co)European Americans (468 ca/419 co)Latinos (603 ca/572 co)Japanese Americans (725 ca/684 co)Native Hawaiians (112 ca/109 co)
rs7210482p15A0.86 (0.59-1.26)0.87 (0.67-1.12)1.49 (1.19-1.87)1.05 (0.71-1.56)0.52 (0.24-1.12)1.08 (0.94-1.25)0.263.9 × 10−3
EHBP10.050.190.140.040.090.09
rs26607533p12.1T0.97 (0.83-1.14)1.06 (0.81-1.39)1.15 (0.94-1.40)1.30 (1.09-1.55)0.94 (0.56-1.57)1.11 (1.01-1.21)0.0340.16
0.460.130.200.240.180.26
rs93645546q25.3T1.10 (0.82-1.48)1.06 (0.86-1.30)1.15 (0.95-1.39)1.09 (0.93-1.29)1.07 (0.69-1.68)1.10 (1.00-1.21)0.0620.99
SLC22A30.070.270.210.340.220.22
rs104865677p15.2G1.18 (1.00-1.40)1.50 (1.19-1.89)1.19 (1.00-1.40)1.14 (0.88-1.48)1.25 (0.83-1.89)1.23 (1.12-1.35)2.1 × 10−50.48
JAZF10.700.740.530.090.360.47
rs64656577q21.3C0.91 (0.72-1.14)1.08 (0.89-1.31)0.94 (0.78-1.12)1.04 (0.82-1.33)0.98 (0.65-1.49)0.99 (0.89-1.09)0.800.77
LMTK20.850.450.700.900.670.75
rs1099399410q11.23T1.05 (0.90-1.24)1.15 (0.96-1.39)1.06 (0.90-1.25)1.26 (1.08-1.46)1.10 (0.75-1.61)1.13 (1.04-1.23)3.1 × 10−30.52
MSMB0.590.420.370.450.640.47
rs1276901910q26.13G1.20 (0.98-1.47)1.12 (0.90-1.39)1.00 (0.83-1.21)1.43 (0.75-2.76)1.42 (0.68-2.95)1.11 (0.99-1.25)0.0620.60
CTBP20.160.260.240.010.070.15
rs793134211q13.2G1.12 (0.93-1.35)1.28 (1.05-1.55)1.27 (1.07-1.51)0.87 (0.73-1.05)1.19 (0.79-1.80)1.13 (1.03-1.23)8.4 × 10−30.023
0.760.510.370.230.480.45
rs1164974317q12G1.04 (0.79-1.38)1.05 (0.82-1.35)1.29 (1.04-1.61)1.08 (0.91-1.27)0.96 (0.65-1.41)1.10 (0.99-1.22)0.0670.58
HNF1B0.910.820.820.700.620.80
rs443079617q12A0.99 (0.84-1.16)1.44 (1.18-1.74)1.26 (1.07-1.50)1.04 (0.89-1.22)1.23 (0.79-1.90)1.15 (1.06-1.25)9.1 × 10−40.026
HNF1B0.350.480.570.640.700.53
rs185996217q24.3G1.01 (0.86-1.19)1.00 (0.83-1.20)1.10 (0.93-1.30)1.06 (0.89-1.25)1.03 (0.69-1.52)1.04 (0.96-1.13)0.350.95
0.320.510.600.260.560.42
rs273583919q13G0.80 (0.67-0.95)1.33 (1.02-1.75)1.15 (0.94-1.40)1.21 (1.03-1.41)0.91 (0.61-1.35)1.06 (0.97-1.16)0.202.0 × 10−3
KLK2/30.710.840.770.580.510.70
rs5945572Xp11.22A1.34 (1.05-1.71)1.25 (0.95-1.66)1.32 (0.98-1.77)1.25 (0.86-1.82)1.65 (0.61-4.46)1.31 (1.13-1.51)2.6 × 10−40.98
NUDT10/110.260.350.170.080.060.19
  • Abbreviations: SNP, single nucleotide polymorphism; Chr., chromosome; ca, cancer; co, control.

  • * ORs were adjusted for age (quintiles), genome-wide European ancestry (African Americans, Latinos, and Native Hawaiians) and age-ethnicity strata (pooled analysis).

  • Phet = P value for heterogeneity of allelic effects across ethnic groups (4 df test).