Table 3.

ERBB2 STR C and invasive breast cancer risk, Shanghai Breast Cancer Study, 1996 to 1998

Stratification (cases/controls)119 Allele carrier
125 Allele carrier
Frequency
OR* (95% CI)PFrequency
OR* (95% CI)P
Cases (%)Controls (%)Cases (%)Controls (%)
All (785/1108)13.48.31.74 (1.27-2.37)0.00117.620.60.78 (0.61-1.00)0.051
Histology
    Lobular-tubular (93/1108)10.88.31.47 (0.73-2.96)0.2788.620.60.34 (0.15-0.74)0.007
    Ductal (619/1108)13.48.31.81 (1.30-2.51)<0.00118.720.60.83 (0.64-1.08)0.174
Combined histologic grade
    3-5 (158/1108)13.98.31.90 (1.13-3.18)0.01515.320.60.68 (0.42-1.10)0.119
    8-9 (344/1108)14.38.31.89 (1.29-2.77)0.00119.520.60.87 (0.63-1.19)0.382
Stage
    TNM 0, I, or IIa (422/1108)11.88.31.51 (1.04-2.19)0.03118.720.60.88 (0.66-1.18)0.388
    TNM IIb, III, or IV (267/1108)15.78.32.09 (1.40-3.12)<0.00115.420.60.69 (0.48-1.00)0.050
  • * Dominant genetic model; noncarriers as the reference group.