Table 2.

Association between LINE-1 methylation and selected demographic and lifestyle variables

Counts*
Overall
Left side
Right side
P
NT/NL/NRMean (95% CI)PMean (95% CI)PMean (95% CI)P
Age (y)
    Q1 (30-52)107/107/10664.75 (64.24-65.26)0.4965.41 (64.81-66.00)0.6364.09 (63.51-64.68)0.460.27
    Q2 (53-58)96/96/9663.94 (63.40-64.48)64.17 (63.55-64.78)63.71 (63.05-64.38)
    Q3 (59-64)93/92/9264.39 (63.87-64.92)64.93 (64.24-65.62)63.87 (63.28-64.45)
    Q4 (65-78)92/92/9164.32 (63.80-64.85)64.92 (64.21-65.62)63.72 (63.17-64.27)
Sex
    Male246/245/24464.33 (64.02-64.64)0.7264.86 (64.45-65.26)0.8563.80 (63.44-64.17)0.660.81
    Female142/141/14264.44 (63.95-64.93)64.92 (64.36-65.48)63.95 (63.43-64.46)
Body mass index (kg/m2)
    Normal113/113/11264.37 (63.87-64.86)0.9364.85 (64.28-65.43)0.7063.89 (63.31-64.47)0.790.77
    Overweight195/195/19364.37 (64.01-64.73)64.84 (64.39-65.29)63.90 (63.49-64.30)
    Obese79/78/7964.40 (63.78-65.02)65.05 (64.24-65.86)63.77 (63.10-64.44)
Smoking
    Never164/164/16364.39 (64.02-64.76)0.4465.12 (64.66-65.57)0.6263.65 (63.23-64.08)0.080.04
    Former163/163/16364.24 (63.82-64.67)64.65 (64.10-65.21)63.84 (63.38-64.30)
    Current60/59/5864.73 (63.96-65.49)64.88 (64.05-65.71)64.57 (63.65-65.50)
Alcohol
    Never123/123/12264.54 (64.13-64.95)0.7465.37 (64.78-65.95)0.1463.70 (63.27-64.14)0.260.02
    1 per day85/84/8564.22 (63.85-64.59)64.65 (64.23-65.08)63.77 (63.30-64.24)
    ≥2 per day165/165/16364.40 (63.69-65.10)64.61 (63.80-65.42)64.19 (63.45-64.95)
Race
    White325/324/32464.27 (63.99-64.55)0.1064.82 (64.47-65.16)0.4363.72 (63.41-64.04)0.020.19
    Black22/22/2164.03 (63.44-64.61)64.84 (63.94-65.75)63.21 (62.43-63.98)
    Hispanic22/22/2265.40 (63.85-66.96)65.38 (63.47-67.28)65.43 (63.81-67.05)
    Other19/19/1965.43 (63.61-67.25)65.52 (63.48-67.55)65.35 (63.56-67.13)
  • * NT = total individuals; NL = total individuals with samples on the left side; NR = total individuals with samples on the right side.

  • Pinteraction testing differences between right and left sides of the colorectum.

  • Ptrend.