Table 9.

QC tools for samples used in proteomics, metabolomics, transcriptomics, or targeted analytical applications

Type of sampleQC toolScope/interpretationReference
PlasmaProtein SStorage duration31
SerumCD40LExposure to RT9
MMP-730 freeze-thaw cycles32
Superoxide dismutase (SOD)5-15 freeze-thaw cycles or 4 d at 37°CF. Betsou, unpublished observations
MMP-9Duration of storage at −80°C33
CSFAmyloid protein Aβ42Freeze-thaw or exposure to RT34
Truncated cystatin C−20°C storage35
TissuesVimentinAntigenicity degradation36
Cyclin-D1Antigenicity degradation37
Phospho-P27Antigenicity degradation37
2-nitroimidazoleTissue hypoxia38
pHTissue hypoxia39
  • NOTE: References contain evidence of the susceptibility of each QC tool to the corresponding preanalytical variation on which interpretation is anticipated.

    Abbreviations: MMP, matrix metalloproteinase; RT, room temperature.