Table 1.

Distribution of one-carbon metabolism genes among breast cancer cases, cases with (M) and without (UM) promoter methylation and controls (Western New York Exposures and Breast Cancer Study, 1996-2001)

ControlsE-cadherin
p16
RAR-β2
M (n = 161)*UM*M (n = 208)*UM*M (n = 221)*UM*
Age, y57.8 ± 11.858.0 ± 11.857.4 ± 11.258.0 ± 11.257.4 ± 11.357.4 ± 11.357.6 ± 11.3
Race/ethnicity
    White1,910 (90.3%)148 (91.9%)594 (92.5%)192 (92.3%)550 (92.4%)210 (95.0%)532 (91.4%)
    Non-white205 (9.7%)13 (8.1%)48 (7.5%)16 (7.7%)45 (7.6%)11 (5.0%)50 (8.6%)
Postmenopausal1,503 (71.1%)111 (68.9%)455 (70.9%)147 (70.7%)419 (70.4%)157 (71.0%)409 (70.3%)
Folate intake (mg/d),267.0 ± 147.3281.7 ± 178.4280.7 ± 178.4§275.2 ± 143.2282.9 ± 158.9§285.5 ± 175.0279.2 ± 146.6
Lifetime alcohol (oz),3,545.6 ± 12,546.93,509.3 ± 6,278.02,901.8 ± 4,766.53,049.5 ± 5,194.33,023.3 ± 5,104.72,626.4 ± 3,703.23,177.4 ± 5,548.6
ER status
    +114 (71.3%)446 (70.0%)136 (65.7%)424 (71.9%)163 (74.8%)397 (68.6%)
    −46 (28.7%)191 (30%)71 (34.3%)166 (28.1%)55 (25.2%)182 (31.4%)
MTR (A2756C)
    AA1,217 (63.1%)99 (65.1%)392 (65.0%)128 (65.7%)363 (64.8%)130 (63.1%)361 (65.8%)
    AG619 (32.1%)47 (30.9%)179 (29.7%)56 (28.7%)170 (30.4%)66 (32.0%)160 (29.1%)
    GG93 (4.8%)6 (4.0%)32 (5.3%)11 (5.6%)27 (4.8%)10 (4.9%)28 (5.1%)
χ2 test, P value0.780.840.74
MTHFR (A1298C)
    AA864 (47.2%)60 (44.8%)249 (47.2%)80 (46.3%)229 (46.8%)79 (43.4%)230 (47.9%)
    AC779 (42.5%)63 (47.0%)224 (42.4%)76 (43.9%)211 (43.2%)88 (48.4%)199 (41.5%)
    CC188 (10.3%)11 (8.2%)55 (40.4%)17 (9.8%)49 (10.0%)15 (8.2%)51 (10.6%)
χ2 test, P value0.560.980.25
MTHFR (C677T)
    CC813 (43.9%)63 (44.7%)260 (45.1%)83 (44.1%)240 (45.4%)93 (47.4%)230 (44.2%)
    CT816 (44.1%)57 (40.4%)248 (43.1%)74 (39.4%)231 (43.7%)87 (44.4%)218 (41.8%)
    TT223 (12.0%)21 (14.9%)68 (11.8%)31 (16.5%)58 (10.9%)16 (8.2%)73 (14.0%)
χ2 test, P value0.590.130.11
  • NOTE: Subjects with missing values were excluded from the analysis.

  • * M, methylated; UM, unmethylated.

  • Mean ± SD.

  • Dietary folate intake.

  • § Comparison of unmethylated cases to controls (P < 0.05).

  • Among ever drinkers.