Table 3.

Rate ratios (95% confidence intervals) of invasive epithelial ovarian cancer by quartiles of acrylamide intake in 1997 among 36,442 women in the Swedish Mammography Cohort, 1998−2007

Quartile of acrylamide intake, μg/d
<20.520.5-24.624.7-29.1≥29.2Ptrend
All women
    Cases, n32343236
    Person-years86,19286,85487,00287,528
    Age-adjusted model1.001.06 (0.65-1.71)0.99 (0.61-1.62)1.11 (0.69-1.79)0.71
    Multivariable model 1*1.001.10 (0.68-1.78)1.04 (0.63-1.69)1.18 (0.73-1.90)0.56
    Multivariable model 21.001.09 (0.67-1.77)1.03 (0.63-1.69)1.17 (0.72-1.89)0.56
Never smokers
    Cases, n18231915
    Multivariable model 1*1.001.32 (0.71-2.45)1.10 (0.57-2.09)0.97 (0.49-1.93)0.80
Ever smokers
    Cases, n14111321
    Multivariable model 1*1.000.83 (0.38-1.84)0.90 (0.42-1.96)1.42 (0.71-2.82)0.24
  • * Adjusted for age, education (primary school, high school, university), body mass index (<18.5, 18.5-24.9, 25-29.9, ≥30 kg/m2), parity (nulliparous, 1-2, ≥3), age at first childbirth (nulliparous, <26, 26-30, ≥31 y), age at menarche (≤12, 13, ≥14 y), age at menopause (<51, ≥51 y), use of oral contraceptives (ever/never), use of postmenopausal hormones (ever/never), and total energy intake (kcal/d).

  • Adjusted for the same variables as in model 1 and additionally for smoking status (never, past, and current smoker).