Table 2.

Rate ratios (95% confidence intervals) of invasive epithelial ovarian cancer by quartiles of long-term acrylamide intake among 61,057 women in the Swedish Mammography Cohort, 1987−2007

Quartile of acrylamide intake, μg/d
<19.919.9-24.224.3-28.8≥28.9Ptrend
Total ovarian cancer
    Cases, n104929478
    Person-years261,196267,092270,165270,815
    Age-adjusted model1.000.87 (0.65-1.17)0.91 (0.68-1.20)0.82 (0.61-1.11)0.25
    Multivariable model 1*1.000.90 (0.68-1.20)0.96 (0.72-1.28)0.84 (0.62-1.14)0.33
    Multivariable model 21.000.91 (0.68-1.21)0.97 (0.73-1.29)0.86 (0.63-1.16)0.39
Serous ovarian cancer
    Cases, n47504540
    Age-adjusted model1.001.05 (0.70-1.57)0.96 (0.63-1.46)0.96 (0.62-1.49)0.78
    Multivariable model 1*1.001.10 (0.73-1.66)1.04 (0.68-1.59)1.01 (0.65-1.56)0.97
    Multivariable model 21.001.13 (0.75-1.70)1.08 (0.70-1.65)1.05 (0.68-1.63)0.88
  • * Adjusted for age, education (primary school, high school, university), body mass index (<18.5, 18.5-24.9, 25-29.9, ≥30 kg/m2), parity (nulliparous, 1-2, ≥3), age at first childbirth (nulliparous, <26, 26-30, ≥31 y), age at menarche (≤12, 13, ≥14 y), age at menopause (<51, ≥51 y), use of oral contraceptives (ever/never), use of postmenopausal hormones (ever/never), and total energy intake (kcal/d).

  • Adjusted for the same variables as in model 1 and additionally for quartiles of intakes of dietary fat, carbohydrate, and fiber.