Table 2.

Observed and predicted prevalence of BRCA1 and BRCA2 mutation carriage in African American, Hispanic, and NHW breast cancer patients, by age at diagnosis and family history of breast cancer

No. of patients*
Carrier prevalence (%)*
Category A
Category B
ObservedBRCAPROPBOADICEAP
TestedPositiveTestedPositive
African American
    All patients2031619523.04.20.115.00.02
    Age (y)
        <50102137915.06.30.366.40.34
        50-64101311611.42.60.173.90.01
    Family history§
        Positive1208805.712.5<0.0112.40.01
        Negative83818722.32.20.863.20.30
Hispanic
    All patients2442518196.43.80.044.30.10
    Age (y)
        <50146218148.05.00.095.40.16
        50-6498410054.82.80.243.20.34
    Family history§
        Positive122140011.515.80.1414.30.33
        Negative1221118195.62.00.012.80.04
NHW
    All patients486315625.04.80.885.50.81
    Age (y)
        <502412117210.58.30.648.10.61
        50-64245103901.92.80.334.00.03
    Family history§
        Positive32821205.713.9<0.0114.2<0.001
        Negative158105424.82.10.232.90.40
  • NOTE: Observed and predicted prevalences according to BRCAPRO and BOADICEA carrier prediction models.

  • * Weighted to account for the two-stage sampling, as described in the text.

  • Under the null hypothesis that observed and predicted mutations are equal.

  • Obtained by adding 0.5 to the 0 count for category B.

  • § Having first-degree relative with breast or ovarian cancer.