Table 2.

Tumor MSI status versus age, sex, and anatomic location

Age at diagnosis (y)MSS
MSI-L
MSI-H
P
Wgt N*Row %Wgt N*Row %Wgt N*Row %
MalesAll colorectal cancers<4059.255.314.214.828.629.9<0.001
40-49306.569.958.314.462.315.7
50-59848.979.8146.613.965.06.3
60-691035.074.4190.913.0183.812.6
≥70564.871.6153.718.188.010.4
Distal<4038.463.210.219.410.217.40.12
40-49210.475.241.116.226.88.6
50-59599.383.198.113.922.73.0
60-69662.683.5121.314.223.02.2
≥70392.881.773.313.430.04.9
Proximal<4014.436.94.011.717.451.50.09
40-4965.958.615.616.425.925.1
50-59157.668.338.215.935.315.8
60-69264.859.339.08.3150.132.4
≥70146.264.241.015.748.020.0
FemalesAll colorectal cancers<4094.073.38.06.126.420.7<0.001
40-49367.275.767.113.652.810.8
50-59630.777.2105.112.983.910.0
60-69670.371.280.68.4192.920.4
≥70354.058.180.112.8177.529.0
Distal<4074.684.56.07.110.68.40.02
40-49258.587.229.710.110.62.7
50-59421.085.955.111.316.02.8
60-69409.284.329.35.855.79.9
≥70212.178.322.98.348.313.4
Proximal<4018.451.02.04.214.844.80.12
40-4983.462.621.815.130.722.3
50-59156.560.947.616.960.822.2
60-69230.159.641.29.6125.330.8
≥7093.138.154.619.9114.242.0
  • * Per text, these are estimated numbers of probands corrected for proband weighting based on ascertainment criteria.

  • Percentage adjusting for center from polytomous logistic regression.

  • Heterogeneity test across the explanatory variable in polytomous logsitic after adjustment.