Table 1.

Characteristics of cases and controls by type of study design

Study nameCountry (substudy)Cases
ControlsDiagnosis
Among controls
HPV detection method
InvasiveCIN3/in situMedian yearMedian age≥2 sexual partnersMedian age at first intercourse
Cohort
    Sweden (29)Sweden037837819873481%17PCR
    Manchester (30)UK019918119893278%18PCR
    Portland Kaiser (31)USA06926319923070%18PCR
    Copenhagen (32)Denmark019075419922694%16PCR
    Guanacaste (33)Costa Rica4212968319933841%18PCR
    Total429652,259
Population case-control
    Los Angeles squamous (34)USA200019819814446%19None
    Brinton US (35)USA47729179119834162%18None
    Male Factor (36)Denmark5958660719853189%18None
    London CIN (37)UK022452819852983%18None
    UK case-control (38)UK578092819863555%18Serology
    Los Angeles adeno (39)USA1415337319863774%18None
    IARC (40)Colombia (invasive)218017719874541%18PCR
Spain (invasive)24802311987539%23PCR
    North Thames invasive (41)UK119024219883471%18None
    Daling Seattle (42, 43)USA6731901,42119924070%18Serology
    US adeno (44)USA1848029919933763%18PCR
    Latvia (45)Latvia219023719995569%20PCR
    Total3,1161,4246,032
Hospital case-control
    WHO (46)Australia374264719803538%19None
Nigeria27014919804030%19None
Philippines15497331981425%20None
Kenya113368119823981%16None
Chile1361541,05119823933%19None
Israel78321,92919823723%19None
Colombia273219419823928%18None
Mexico2771531,46719834119%18None
Thailand (Siriraj)7615042,61319844111%20None
Thailand (Chulalongkorn)5913652,35719844121%20None
Thailand (Chiang Mai)8002032,51419854420%19None
    Milan (47, 48)Italy (invasive)781087819855217%22None
Italy (in situ)027030319854025%20None
    Bangkok (49, 50)Thailand289767611992427%21PCR
    Brinton Latin America (51)Colombia212040719864744%18FISH
Costa Rica191036619864440%18FISH
Mexico155029119864531%19FISH
Panama192030719864858%18FISH
    IARC (52-61)Colombia (CIN3)023426919863741%18PCR
Spain (CIN3)022224119873419%21PCR
Paraguay116010119894824%19PCR
Brazil199022519905033%19PCR
Thailand386035419914918%20PCR
Mali8209719924552%15Serology
Philippines387038619924710%21PCR
Morocco214020319934920%18PCR
Peru198019619964857%18PCR
Algeria198020219985328%18PCR
India20502131998471%18PCR
    Johannesburg (62, 63)South Africa809073819975278%NASerology
    Total7,6152,29920,873
Grand total10,7734,68829,164
  • Abbreviations: NA, not applicable; FISH, fluorescence in situ hybridization.