Table 3.

Cell cycle SNPs and risk of ovarian cancer

GeneSNPDistance (bp)OR (95% CI)
MAY + NCOSEA + MAL + STACombinedCombined imputed: HapMap + NIEHSCombined imputed: HapMap only
CDKN2Crs31764591.00 (0.90-1.10)1.00 (0.90-1.10)0.98 (0.89-1.08)0.98 (0.89-1.08)
rs128552,8461.02 (0.80-1.30)1.01 (0.86-1.19)1.01 (0.89-1.16)1.01 (0.88-1.15)1.01 (0.88-1.15)
CDKN1Ars19771721.11 (0.90-1.38)1.11 (0.90-1.38)1.12 (0.90-1.39)1.09 (0.91-1.31)
rs38299632,6321.19 (0.97-1.46)1.19 (0.97-1.46)1.17 (0.96-1.42)1.06 (0.92-1.22)
rs7335908170.87 (0.75-1.02)0.87 (0.75-1.02)0.98 (0.87-1.10)1.00 (0.93-1.08)
rs7626243851.09 (0.98-1.21)1.09 (0.98-1.21)1.08 (0.97-1.20)1.08 (0.97-1.20)
rs23956551081.10 (1.00-1.21)1.10 (1.00-1.21)1.04 (0.95-1.13)1.03 (0.95-1.11)
rs31763311,8291.02 (0.89-1.18)1.02 (0.89-1.18)1.00 (0.87-1.16)1.01 (0.88-1.17)
rs31763361,2910.97 (0.88-1.07)0.97 (0.88-1.07)0.97 (0.88-1.07)0.97 (0.88-1.07)
rs31763431,4511.05 (0.84-1.30)1.05 (0.84-1.30)1.04 (0.84-1.29)1.04 (0.84-1.29)
rs18012701,7040.95 (0.78-1.15)0.95 (0.78-1.15)0.93 (0.77-1.13)0.95 (0.79-1.15)
rs31763523681.08 (0.97-1.20)1.08 (0.97-1.20)1.08 (0.97-1.20)1.01 (0.92-1.11)
rs10592341,2580.96 (0.79-1.16)0.96 (0.79-1.16)0.96 (0.79-1.17)0.96 (0.79-1.16)
rs64579377540.92 (0.68-1.24)0.92 (0.68-1.24)0.91 (0.68-1.23)0.91 (0.68-1.23)
rs31763593911.61 (0.72-3.56)1.61 (0.72-3.56)1.63 (0.73-3.61)1.63 (0.73-3.61)
rs77672464,4730.82 (0.69-0.99)1.11 (0.98-1.25)1.01 (0.92-1.12)1.00 (0.91-1.11)1.02 (0.92-1.12)
CCND3rs24797260.92 (0.79-1.08)0.92 (0.79-1.08)0.93 (0.80-1.09)0.93 (0.80-1.09)
rs38288552,3100.98 (0.76-1.25)0.98 (0.76-1.25)0.97 (0.76-1.25)0.97 (0.76-1.25)
rs32181141,9460.98 (0.86-1.10)0.98 (0.86-1.10)0.97 (0.86-1.10)0.97 (0.86-1.10)
rs32181101571.09 (0.98-1.22)1.09 (0.98-1.22)1.08 (0.97-1.21)1.08 (0.97-1.21)
rs32181081460.93 (0.79-1.09)0.93 (0.79-1.09)0.93 (0.79-1.10)0.93 (0.79-1.10)
rs95293520.91 (0.78-1.07)0.93 (0.84-1.03)0.93 (0.85-1.01)0.93 (0.85-1.01)0.93 (0.85-1.01)
rs24797172,1671.00 (0.90-1.12)1.00 (0.90-1.12)1.02 (0.92-1.13)1.02 (0.92-1.13)
rs32180921,4870.98 (0.87-1.11)0.98 (0.87-1.11)0.97 (0.86-1.10)0.97 (0.86-1.10)
rs14104921,1941.06 (0.95-1.18)1.06 (0.95-1.18)1.06 (0.95-1.18)1.06 (0.95-1.18)
rs32180862,2091.32 (1.10-1.58)1.32 (1.10-1.58)1.31 (1.09-1.57)1.31 (1.09-1.57)
rs32180851151.17 (0.63-2.17)1.17 (0.63-2.17)1.18 (0.63-2.20)1.18 (0.63-2.20)
rs93811001,0060.90 (0.76-1.06)0.90 (0.76-1.06)0.89 (0.75-1.05)0.89 (0.75-1.05)
CDKN2A—Brs37312570.89 (0.80-1.00)0.89 (0.80-1.00)0.89 (0.80-1.00)0.93 (0.85-1.03)
rs30884401,9381.08 (0.91-1.28)1.08 (0.91-1.28)1.00 (0.86-1.16)1.07 (0.91-1.26)
rs11515401.07 (0.94-1.23)1.07 (0.94-1.23)1.06 (0.92-1.21)0.98 (0.87-1.10)
rs37312492,7170.92 (0.62-1.35)0.89 (0.67-1.19)0.91 (0.72-1.14)0.90 (0.72-1.14)0.90 (0.72-1.14)
rs37312393,3021.05 (0.95-1.16)1.05 (0.95-1.16)1.08 (0.99-1.18)1.11 (1.02-1.20)
rs28117095,9330.80 (0.64-0.99)0.80 (0.64-0.99)0.79 (0.64-0.99)0.96 (0.85-1.08)
rs40747851,4321.09 (0.92-1.28)1.09 (0.92-1.28)1.08 (0.92-1.28)1.10 (0.93-1.29)
rs37312222,3310.96 (0.83-1.10)0.96 (0.83-1.10)0.96 (0.84-1.11)0.92 (0.82-1.04)
rs37312112,9330.98 (0.88-1.09)0.98 (0.88-1.09)0.97 (0.88-1.08)0.92 (0.84-1.00)
rs70366563,6100.79 (0.67-0.93)0.79 (0.67-0.93)0.79 (0.67-0.92)0.94 (0.86-1.02)
rs37311979141.03 (0.93-1.13)1.03 (0.93-1.13)1.02 (0.93-1.11)1.03 (0.93-1.13)
rs32180206,5010.99 (0.89-1.10)0.99 (0.89-1.10)0.98 (0.89-1.07)1.00 (0.91-1.09)
rs28117121631.05 (0.90-1.22)1.05 (0.90-1.22)1.04 (0.89-1.21)0.95 (0.84-1.08)
rs32180126251.00 (0.91-1.10)1.00 (0.91-1.10)0.98 (0.90-1.06)0.98 (0.89-1.08)
rs3218009971.19 (0.96-1.46)0.99 (0.86-1.14)1.05 (0.93-1.17)1.04 (0.93-1.17)1.04 (0.93-1.17)
rs32180051,4901.06 (0.91-1.25)1.06 (0.91-1.25)1.02 (0.88-1.18)0.95 (0.84-1.09)
rs32179922,9760.97 (0.88-1.08)0.97 (0.88-1.08)0.96 (0.87-1.05)0.98 (0.90-1.06)
rs10631921441.09 (0.94-1.25)0.98 (0.89-1.08)1.01 (0.94-1.10)1.01 (0.93-1.09)1.02 (0.94-1.10)
rs32179861,9631.10 (0.93-1.29)1.10 (0.93-1.29)1.08 (0.92-1.27)1.09 (0.92-1.28)
rs20694184,3681.11 (0.97-1.28)1.11 (0.97-1.28)1.13 (0.98-1.31)1.13 (0.98-1.31)
rs5754271,7790.84 (0.66-1.07)0.84 (0.66-1.07)0.83 (0.65-1.07)0.91 (0.79-1.04)
rs132988815740.94 (0.75-1.19)0.94 (0.75-1.19)0.92 (0.73-1.17)1.09 (0.95-1.25)
rs108116401,3600.97 (0.84-1.12)0.97 (0.84-1.12)0.96 (0.83-1.10)0.99 (0.91-1.07)
CCND1rs6026521.11 (1.01-1.23)1.11 (1.01-1.23)1.08 (1.00-1.17)1.14 (1.04-1.25)
rs38627922140.79 (0.58-1.09)0.79 (0.58-1.09)0.79 (0.58-1.09)0.79 (0.58-1.09)
rs603965541.01 (0.88-1.17)1.12 (1.02-1.23)1.09 (1.00-1.17)1.08 (1.00-1.17)1.08 (1.00-1.17)
rs32128795710.91 (0.83-1.00)0.91 (0.83-1.00)0.93 (0.86-1.01)0.90 (0.82-0.99)
rs6493921,3121.00 (0.87-1.14)1.00 (0.87-1.14)0.93 (0.86-1.01)0.92 (0.85-1.00)
rs32128917140.90 (0.82-1.00)0.90 (0.82-1.00)0.93 (0.86-1.00)0.90 (0.82-0.99)
rs6786531,2301.01 (0.87-1.17)0.96 (0.87-1.06)0.97 (0.90-1.06)0.97 (0.90-1.06)0.97 (0.90-1.06)
rs71782,2930.83 (0.64-1.09)1.21 (1.02-1.45)1.08 (0.93-1.24)1.07 (0.93-1.24)1.07 (0.93-1.24)
rs116035413,3430.90 (0.72-1.13)0.90 (0.72-1.13)0.90 (0.72-1.14)0.91 (0.72-1.14)
CCND2rs10496061.06 (0.92-1.22)1.06 (0.92-1.22)1.04 (0.94-1.15)1.08 (0.95-1.22)
rs32177953,0280.95 (0.80-1.12)0.95 (0.80-1.12)0.95 (0.80-1.12)0.95 (0.80-1.12)
rs32178052,0200.96 (0.87-1.06)0.96 (0.87-1.06)1.01 (0.92-1.11)1.01 (0.92-1.11)
rs32178202,2881.03 (0.93-1.14)1.03 (0.93-1.14)0.95 (0.87-1.05)0.95 (0.87-1.05)
rs32178527,3940.97 (0.87-1.09)0.97 (0.87-1.09)0.98 (0.88-1.10)0.99 (0.89-1.10)
rs32178621,3210.95 (0.83-1.08)0.95 (0.83-1.08)0.95 (0.84-1.08)0.95 (0.83-1.07)
rs32178634091.05 (0.88-1.26)1.05 (0.88-1.26)1.05 (0.89-1.25)1.08 (0.91-1.28)
rs32178694741.02 (0.93-1.13)1.02 (0.93-1.13)1.01 (0.92-1.10)1.02 (0.93-1.10)
rs32179015,4191.03 (0.93-1.13)1.03 (0.93-1.13)1.01 (0.93-1.10)1.01 (0.93-1.10)
rs32179064151.03 (0.92-1.14)1.03 (0.92-1.14)1.02 (0.92-1.14)1.02 (0.92-1.13)
rs32179162,8690.92 (0.83-1.02)0.92 (0.83-1.02)0.94 (0.85-1.04)0.95 (0.87-1.03)
rs32179252,9660.91 (0.81-1.01)0.91 (0.81-1.01)0.92 (0.83-1.01)0.94 (0.85-1.02)
rs3217926441.03 (0.89-1.20)0.98 (0.89-1.08)0.99 (0.92-1.08)0.99 (0.91-1.07)0.99 (0.91-1.07)
rs10496121,0791.04 (0.90-1.20)1.04 (0.90-1.20)0.99 (0.88-1.12)1.03 (0.93-1.13)
rs32179332380.95 (0.80-1.12)1.09 (0.97-1.21)1.04 (0.95-1.14)1.04 (0.95-1.14)1.04 (0.95-1.14)
rs32179361,9520.91 (0.82-1.01)0.91 (0.82-1.01)0.94 (0.85-1.02)0.94 (0.87-1.03)
CDKN1Brs37592161.05 (0.91-1.21)1.02 (0.93-1.13)1.03 (0.95-1.12)1.03 (0.95-1.11)1.02 (0.94-1.10)
rs37592173661.06 (0.86-1.31)1.14 (0.99-1.32)1.11 (0.99-1.26)1.11 (0.99-1.25)1.12 (0.99-1.26)
rs343302,2430.94 (0.80-1.11)0.91 (0.81-1.02)0.92 (0.84-1.01)0.92 (0.84-1.01)0.92 (0.84-1.01)
rs20668274040.84 (0.75-0.94)0.84 (0.75-0.94)0.84 (0.76-0.94)0.85 (0.77-0.94)
rs343292,1341.12 (0.96-1.30)1.00 (0.90-1.11)1.04 (0.95-1.13)1.03 (0.95-1.13)1.03 (0.95-1.12)
rs3093736681.07 (0.72-1.59)0.97 (0.75-1.26)1.00 (0.80-1.24)0.99 (0.80-1.23)0.99 (0.80-1.23)
rs73301,6161.05 (0.91-1.21)1.01 (0.92-1.11)1.02 (0.94-1.10)1.02 (0.94-1.10)1.02 (0.94-1.11)
rs14200231,1940.84 (0.68-1.05)0.98 (0.84-1.14)0.94 (0.83-1.06)0.93 (0.82-1.06)0.93 (0.82-1.06)
rs343223,4590.98 (0.85-1.13)0.98 (0.85-1.13)0.97 (0.84-1.12)1.02 (0.94-1.11)
CDK2rs20693911.16 (0.89-1.52)1.16 (0.89-1.52)1.15 (0.88-1.50)1.21 (1.02-1.43)
rs20694084,4430.94 (0.80-1.09)0.94 (0.84-1.04)0.94 (0.86-1.02)0.93 (0.85-1.01)0.93 (0.85-1.01)
rs20694141,3781.55 (1.18-2.04)1.55 (1.18-2.04)1.58 (1.20-2.09)1.58 (1.20-2.09)
rs10454354611.17 (0.90-1.53)1.14 (0.97-1.34)1.15 (1.00-1.32)1.14 (1.00-1.31)1.14 (1.00-1.31)
rs111717101,9181.06 (0.92-1.22)1.06 (0.92-1.22)1.07 (0.93-1.23)1.05 (0.95-1.17)
rs175287364401.15 (0.78-1.70)1.15 (0.78-1.70)1.13 (0.77-1.67)1.23 (1.01-1.48)
rs7731081,3930.93 (0.80-1.08)0.93 (0.80-1.08)0.92 (0.79-1.08)0.92 (0.85-1.00)
CDK4rs20695060.99 (0.89-1.09)0.99 (0.89-1.09)1.00 (0.92-1.08)0.99 (0.90-1.09)
rs20695021,8111.02 (0.88-1.18)1.02 (0.88-1.18)1.00 (0.92-1.08)1.00 (0.89-1.12)
rs22707774910.90 (0.78-1.03)1.03 (0.93-1.13)0.99 (0.91-1.07)0.99 (0.91-1.07)0.99 (0.91-1.07)
rs20720521,5631.03 (0.89-1.19)1.03 (0.89-1.19)1.00 (0.92-1.08)1.03 (0.89-1.20)
RB1rs19814340.97 (0.87-1.08)0.97 (0.87-1.08)0.97 (0.88-1.08)0.98 (0.90-1.07)
rs285434510,0821.00 (0.89-1.12)1.00 (0.89-1.12)1.00 (0.88-1.12)1.00 (0.88-1.12)
rs415146728,6871.07 (0.78-1.45)1.07 (0.78-1.45)1.09 (0.80-1.48)1.09 (0.80-1.48)
rs732993812,0561.08 (0.87-1.33)1.08 (0.87-1.33)1.08 (0.88-1.33)1.09 (0.88-1.35)
rs415151013,1961.08 (0.88-1.34)1.08 (0.88-1.34)1.08 (0.95-1.24)1.10 (0.89-1.36)
rs3994133,3941.02 (0.91-1.14)1.02 (0.91-1.14)0.96 (0.88-1.06)1.00 (0.91-1.09)
rs41515407,0910.96 (0.86-1.07)0.96 (0.86-1.07)0.94 (0.85-1.03)0.96 (0.86-1.07)
rs956803616,2761.03 (0.89-1.19)1.03 (0.89-1.19)1.03 (0.89-1.19)1.00 (0.91-1.10)
rs19860412,1271.00 (0.84-1.17)1.00 (0.84-1.17)1.00 (0.85-1.18)0.98 (0.89-1.07)
rs41515511,3761.10 (0.85-1.41)1.06 (0.90-1.25)1.07 (0.93-1.23)1.06 (0.93-1.22)1.06 (0.93-1.22)
rs285434412,2540.97 (0.73-1.28)0.81 (0.66-0.99)0.87 (0.74-1.02)0.88 (0.75-1.04)0.88 (0.75-1.04)
rs42583414,8001.04 (0.80-1.36)1.04 (0.80-1.36)1.05 (0.81-1.37)1.05 (0.81-1.37)
rs415161135,4380.91 (0.72-1.14)0.91 (0.72-1.14)0.90 (0.71-1.13)0.89 (0.71-1.13)
rs41516201,1281.00 (0.85-1.17)1.00 (0.85-1.17)1.04 (0.90-1.20)1.02 (0.87-1.20)
rs30929042,4220.98 (0.87-1.10)0.98 (0.87-1.10)0.96 (0.86-1.07)0.97 (0.89-1.07)
rs41516365,2530.93 (0.74-1.17)0.93 (0.74-1.17)0.92 (0.73-1.16)0.92 (0.73-1.15)
rs9908142,8431.00 (0.85-1.17)1.00 (0.85-1.17)1.01 (0.86-1.18)0.98 (0.90-1.08)
CDKN2Drs32182221.02 (0.91-1.14)1.02 (0.91-1.14)1.01 (0.91-1.12)1.01 (0.91-1.12)
rs14657021,9511.10 (0.88-1.39)1.10 (0.88-1.39)1.05 (0.86-1.29)1.05 (0.86-1.29)
rs14657012101.15 (0.97-1.35)1.15 (0.97-1.35)1.16 (0.98-1.36)1.16 (0.98-1.36)
rs176773161,3990.90 (0.76-1.06)0.90 (0.76-1.06)0.89 (0.75-1.05)0.89 (0.75-1.05)
CCNE1rs9976690.97 (0.84-1.13)1.07 (0.97-1.18)1.04 (0.96-1.13)1.04 (0.96-1.13)1.04 (0.96-1.13)
rs32180361,2011.11 (1.00-1.23)1.11 (1.00-1.23)1.07 (0.98-1.17)1.12 (1.01-1.24)
rs32180382111.03 (0.80-1.33)1.03 (0.80-1.33)1.02 (0.84-1.24)1.02 (0.79-1.32)
rs14069,2170.99 (0.84-1.18)0.99 (0.84-1.18)0.98 (0.89-1.08)1.00 (0.92-1.10)
rs32180761581.02 (0.91-1.13)1.02 (0.91-1.13)1.01 (0.92-1.11)1.00 (0.92-1.10)
  • NOTE: Bold emphasis indicates P < 0.05.