Table 5.

Association between LINE-1 methylation and selected polymorphisms

Counts*
Overall
Left side
Right side
P
NT/NL/NRMean (95% CI)PMean (95% CI)PMean (95% CI)P
MTHFR-C677T
    CC156/156/15664.44 (64.02-64.86)0.5365.05 (64.54-65.56)0.8963.84 (63.34-64.34)0.320.26
    CT156/156/15564.25 (63.85-64.65)64.65 (64.14-65.16)63.86 (63.42-64.29)
    TT45/44/4364.16 (63.38-64.94)64.97 (63.98-65.95)63.36 (62.56-64.16)
MTHFR-A1298C
    AA174/173/17264.04 (63.69-64.39)0.4464.57 (64.16-64.98)0.3063.52 (63.10-63.95)0.870.65
    AC142/142/14164.64 (64.18-65.10)65.12 (64.51-65.72)64.16 (63.68-64.65)
    CC39/39/3964.42 (63.52-65.33)65.21 (64.05-66.37)63.62 (62.59-64.64)
MTR-A2756G
    AA244/244/24364.28 (63.95-64.61)0.3964.78 (64.37-65.20)0.3663.77 (63.41-64.14)0.880.72
    AG101/100/9964.39 (63.87-64.91)64.95 (64.33-65.58)63.82 (63.22-64.43)
    GG12/12/1264.72 (63.78-65.67)65.60 (63.91-67.29)63.84 (63.07-64.61)
MTRR-A66G
    AA88/88/8664.59 (64.06-65.13)0.4865.43 (64.75-66.11)0.1363.76 (63.15-64.36)0.680.14
    AG168/168/16864.19 (63.79-64.59)64.64 (64.14-65.15)63.74 (63.29-64.19)
    GG99/98/9864.33 (63.82-64.83)64.72 (64.11-65.33)63.93 (63.35-64.52)
CBS-C1080T
    CC169/168/16864.22 (63.81-64.62)0.8664.84 (64.35-65.32)0.7063.60 (63.12-64.07)0.440.55
    CT150/150/14864.46 (64.04-64.88)64.93 (64.39-65.48)63.98 (63.53-64.42)
    TT36/36/3664.30 (63.53-65.06)64.61 (63.59-65.64)63.98 (63.15-64.81)
CBS-C699T
    CC153/153/15164.49 (64.07-64.91)0.7464.88 (64.34-65.41)0.4764.10 (63.65-64.55)0.820.37
    CT170/169/16964.12 (63.73-64.50)64.75 (64.27-65.22)63.49 (63.05-63.93)
    TT33/33/3364.66 (63.80-65.51)64.33 (64.21-66.45)63.96 (62.84-65.09)
  • * NT = total individuals; NL = total individuals with samples on the left side; NR = total individuals with samples on the right side.

  • Pinteraction testing differences between right and left sides of the colorectum.

  • Ptrend.