Table 4.

Association between LINE-1 methylation and circulating levels of B vitamins and homocysteine

Counts*
Overall
Left side
Right side
P
NT/NL/NRMean (95% CI)PMean (95% CI)PMean (95% CI)P
Plasma folate (nmol/L)
    Q1 (3.14-10.02)93/93/9164.80 (64.32-65.28)0.2265.33 (64.69-65.97)0.4364.26 (63.69-64.84)0.220.88
    Q2 (10.05-16.70)92/92/9264.12 (63.53-64.70)64.52 (63.80-65.24)63.71 (63.09-64.33)
    Q3 (16.73-27.26)93/92/9264.20 (63.66-64.73)64.70 (64.01-65.39)63.71 (63.08-64.34)
    Q4 (27.31-119.0)92/92/9264.30 (63.77-64.83)64.88 (64.26-65.50)63.72 (63.13-64.31)
RBC folate (ng/mL)
    Q1 (64.86-303.0)98/98/9664.07 (63.69-64.46)0.9964.41 (63.89-64.93)0.6663.72 (63.23-64.22)0.660.68
    Q2 (304.0-383.0)96/96/9564.58 (63.94-65.21)65.13 (64.37-65.90)64.02 (63.30-64.73)
    Q3 (384.0-468.0)98/97/9864.92 (64.32-65.53)65.55 (64.83-66.26)64.30 (63.64-64.95)
    Q4 (469.0-952.0)95/94/9563.95 (63.50-64.41)64.47 (63.88-65.06)63.45 (62.94-63.96)
Plasma B2 (nmol/L)
    Q1 (2.54-8.93)93/92/9164.62 (63.99-65.24)0.4564.81 (64.11-65.52)0.7164.42 (63.68-65.17)0.080.17
    Q2 (9.10-14.70)93/93/9264.31 (63.75-64.86)64.88 (64.22-65.55)63.72 (63.06-64.38)
    Q3 (14.90-23.70)93/92/9364.18 (63.73-64.64)64.67 (64.07-65.27)63.71 (63.19-64.22)
    Q4 (23.80-468.5)92/92/9264.34 (63.83-64.84)65.08 (64.38-65.79)63.59 (63.11-64.07)
Plasma B6 (nmol/L)
    Q1 (9.74-36.0)94/94/9264.27 (63.69-64.84)0.2964.38 (63.71-65.06)0.0464.15 (63.44-64.84)0.760.11
    Q2 (36.1-51.2)93/92/9264.08 (63.51-64.65)64.69 (63.96-65.42)63.47 (62.88-64.06)
    Q3 (52.1-79.8)92/91/9264.57 (64.06-65.08)65.14 (64.51-65.77)64.00 (63.40-64.60)
    Q4 (80.7-857)92/92/9264.53 (64.07-65.00)65.25 (64.63-65.86)63.83 (63.32-64.34)
Plasma B12 (pmol/L)
    Q1 (43.90-240.7)93/92/9164.34 (63.69-64.99)0.5864.68 (63.91-65.45)0.8563.99 (63.29-64.69)0.450.75
    Q2 (242.7-307.1)93/93/9364.62 (64.04-65.19)65.25 (64.47-66.04)63.98 (63.37-64.59)
    Q3 (307.7-400.8)93/92/9364.26 (63.83-64.69)64.77 (64.22-65.31)63.75 (63.20-64.30)
    Q4 (400.9-2072)93/93/9264.23 (63.78-64.67)64.75 (64.22-65.27)63.71 (63.16-64.26)
Homocysteine (μmol/L)
    Q1 (4.73-7.92)93/93/9264.23 (63.72-64.74)0.8664.89 (64.29-65.48)0.8263.58 (63.03-64.13)0.560.70
    Q2 (7.94-9.25)93/93/9364.35 (63.85-64.85)64.77 (64.07-65.46)63.94 (63.93-64.49)
    Q3 (9.29-11.10)93/91/9264.62 (64.08-65.17)65.14 (64.57-65.71)64.11 (63.38-64.83)
    Q4 (11.18-23.30)92/92/9164.21 (63.62-64.79)64.64 (63.85-65.44)63.78 (63.22-64.33)
  • * NT = total individuals; NL = total individuals with samples on the left side; NR = total individuals with samples on the right side.

  • Pinteraction testing differences between right and left sides of the colorectum.

  • Ptrend.