Table 3.

Association between LINE-1 methylation and dietary intake of B-vitamin and multivitamin use

Counts*
Overall
Left side
Right side
P
NT/NL/NRMean (95% CI)PMean (95% CI)PMean (95% CI)P
Dietary folate (μg/d)
    Q1 (78.08-205.86)94/94/9364.66 (64.09-65.23)0.0264.85 (64.18-65.51)0.3264.47 (63.83-65.11)<0.010.10
    Q2 (206.87-277.3)94/94/9464.82 (64.69-65.32)65.47 (64.79-66.16)64.16 (63.59-64.73)
    Q3 (277.31-373.65)94/94/9364.05 (63.55-64.56)64.57 (63.95-65.19)63.53 (62.94-64.12)
    Q4 (376.17-1,285.59)93/91/9263.92 (63.36-64.48)64.63 (63.96-65.31)63.22 (62.61-63.82)
Dietary B2 (mg/d)
    Q1 (0.39-1.18)98/98/9764.73 (64.18-65.28)0.5765.22 (64.52-65.92)0.7564.24 (63.67-64.82)0.160.12
    Q2 (1.19-1.57)92/92/9264.17 (63.64-64.70)64.36 (63.73-65.00)63.97 (63.33-64.61)
    Q3 (1.60-2.20)92/92/9264.03 (63.56-64.48)64.66 (64.03-65.30)63.39 (62.89-63.89)
    Q4 (2.21-6.56)93/91/9164.53 (63.93-65.13)65.29 (64.62-65.96)63.77 (63.09-64.45)
Dietary B6 (mg/d)
    Q1 (0.33-1.08)99/99/9964.72 (64.17-65.28)0.1764.99 (64.31-65.66)0.7764.46 (63.87-65.04)0.040.32
    Q2 (1.09-1.54)89/89/8864.23 (63.68-64.78)64.76 (64.13-65.39)63.70 (63.05-64.35)
    Q3 (1.55-2.00)95/95/9464.38 (63.90-64.86)65.02 (64.32-65.71)63.76 (63.25-64.27)
    Q4 (2.01-6.20)92/90/9164.11 (63.56-64.65)64.76 (64.12-65.39)63.45 (62.80-64.11)
Multivitamin use
    No256/255/25364.22 (63.90-64.53)0.1264.72 (64.31-65.13)0.1863.71 (63.35-64.06)0.100.97
    Yes130/130/13064.67 (64.20-65.13)65.19 (64.65-65.72)64.15 (63.61-64.70)
  • NOTE: Quartiles of the residuals of the regression of the logarithm of the nutrient on the logarithm of kilocalories. Means are adjusted for energy intake using the logarithm of caloric intake. Quartiles ranges are based in a 2,000 calories/d diet.

  • * NT = total individuals; NL = total individuals with samples on the left side; NR = total individuals with samples on the right side.

  • Pinteraction testing differences between right and left sides of the colorectum.

  • Ptrend.