Table 3.

Multivariate Cox proportional hazards regression model

FactorHR (95% CI)P
ECOG PS5.749 (1.862-16.09)0.002
T classification1.851 (1.109-3.090)0.019
Fuhrman grade0.922 (0.480-1.771)0.808
Ki-671.053 (1.010-1.099)0.016
p531.039 (1.012-1.067)0.005
p21 (nuclear)0.994 (0.971-1.018)0.646
VEGFR-1 (endothelial)1.050 (1.019-1.081)0.002
VEGFR-1 (epithelial)1.025 (1.007-1.042)0.007
VEGF-D (epithelial)0.970 (0.955-0.985)<0.001
  • NOTE: T classification, ECOG PS, Ki-67, p53, epithelial and endothelial VEGFR-1, and epithelial VEGF-D expression were retained as independent prognostic factors of DFS.