Table 2.

Univariate Cox regression analysis

HR (95% CI)P
Clinicopathologic factors
    ECOG PS4.610 (2.077-10.23)<0.001
    T classification2.889 (1.918-4.352)<0.001
    Tumor size1.234 (1.147-1.329)<0.001
    Fuhrman grade2.073 (1.215-3.537)0.008
    UISS group5.032 (2.856-8.865)<0.001
Molecular markers
    p531.042 (1.020-1.065)<0.001
    VEGF-D (epithelial)0.980 (0.968-0.992)0.002
    VEGFR-1 (endothelial)1.038 (1.014-1.063)0.002
    VEGFR-1 (epithelial)1.017 (1.004-1.029)0.008
    Ki-671.041 (1.004-1.079)0.028
    p21 (nuclear)0.980 (0.962-0.999)0.037
    p27 (nuclear)0.984 (0.966-1.002)0.079
    pS61.009 (0.999-1.019)0.087
    CAXII0.990 (0.978-1.002)0.099
    VEGF-A (epithelial)1.009 (0.997-1.020)0.158
    EpCAM0.987 (0.969-1.006)0.173
    p21 (cytoplasmic)0.979 (0.942-1.016)0.263
    VEGF-D (endothelial)0.835 (0.600-1.162)0.286
    Gelsolin1.005 (0.996-1.014)0.312
    pAkt (nuclear)0.990 (0.969-1.011)0.340
    VEGF-A (endothelial)1.007 (0.993-1.021)0.350
    VEGF-C (epithelial)1.007 (0.993-1.021)0.351
    Vimentin1.006 (0.993-1.019)0.358
    CXCR30.996 (0.984-1.008)0.497
    pAkt (cytoplasmic)1.004 (0.992-1.016)0.535
    VEGFR-3 (endothelial)1.003 (0.991-1.016)0.612
    VEGFR-2 (epithelial)1.003 (0.992-1.014)0.613
    CAIX1.003 (0.991-1.015)0.651
    PTEN1.003 (0.990-1.016)0.653
    VEGF-C (endothelial)1.006 (0.977-1.036)0.702
    p27 (cytoplasmic)0.995 (0.966-1.024)0.723
    VEGFR-3 (epithelial)1.005 (0.973-1.037)0.778
    VEGFR-2 (endothelial)1.004 (0.971-1.038)0.816
    HIF-1α0.999 (0.985-1.013)0.909
  • NOTE: ECOG PS, T classification, tumor size, Fuhrman grade, UISS group, Ki-67, p53, nuclear p21, epithelial and endothelial VEGFR-1, and epithelial VEGF-D expression were all associated with DFS.