Table 1.

Association of recent alcoholic beverage consumption and breast cancer risk

Drinks per weekAll women
Premenopausal women
Postmenopausal women*,
Cases (n = 6,327)Controls (n = 7,558)OR (95% CI)Cases (n = 2,462)Controls (n = 2,925)OR (95% CI)Cases (n = 3,449)Controls (n = 4,162)OR (95% CI)
No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)
All alcohol
    Nondrinkers1,122 (18)1,379 (18)1351 (14)424 (15)1709 (21)876 (21)1
    <12,129 (34)2,712 (36)0.94 (0.85-1.04)894 (36)1,045 (36)1.02 (0.86-1.22)1,106 (32)1,480 (36)0.90 (0.79-1.02)
    1-3.41,450 (23)1,731 (23)0.99 (0.88-1.10)592 (24)767 (26)0.90 (0.75-1.08)745 (22)863 (21)1.03 (0.89-1.19)
    3.5-6.9702 (11)793 (11)1.02 (0.90-1.17)306 (12)363 (12)0.96 (0.78-1.19)345 (10)384 (9)1.05 (0.88-1.26)
    7-13.9619 (10)658 (9)1.11 (0.97-1.28)221 (9)223 (8)1.17 (0.92-1.48)355 (10)395 (10)1.07 (0.89-1.28)
    ≥14305 (5)285 (4)1.24 (1.03-1.49)98 (4)103 (4)1.10 (0.80-1.52)189 (6)164 (4)1.37 (1.08-1.73)
    Ptrend0.0030.550.004
1-drink increase1.01 (1.00-1.02)1.00 (0.99-1.01)1.02 (1.01-1.03)
Wine
    Nondrinkers1,122 (18)1,379 (18)1351 (14)424 (15)1709 (21)876 (21)1
    <12,455 (39)2,920 (39)1.03 (0.94-1.12)1,021 (42)1,183 (40)1.09 (0.95-1.26)1,283 (37)1,550 (37)0.97 (0.86-1.09)
    1-3.41,048 (17)1,248 (17)1.00 (0.89-1.11)424 (17)546 (19)0.98 (0.82-1.17)538 (16)634 (15)0.95 (0.81-1.11)
    3.5-6.9343 (5)363 (5)1.13 (0.95-1.34)134 (5)149 (5)1.15 (0.87-1.50)179 (5)192 (5)1.05 (0.83-1.33)
    7-13.9256 (4)299 (4)1.07 (0.89-1.29)90 (4)86 (3)1.42 (1.02-1.96)147 (4)192 (5)0.93 (0.73-1.19)
    ≥1482 (1)70 (1)1.37 (0.98-1.91)29 (1)24 (1)1.58 (0.90-2.79)47 (1)43 (1)1.23 (0.80-1.90)
    Ptrend0.200.1284
1-drink increase1.01 (0.99-1.02)1.00 (0.99-1.02)1.01 (0.99-1.03)
Beer
    Nondrinkers1,122 (18)1,379 (18)1351 (14)424 (15)1709 (21)876 (21)1
    <11,756 (28)2,040 (27)1.01 (0.93-1.10)714 (29)870 (30)0.92 (0.80-1.05)916 (27)1,044 (25)1.05 (0.94-1.18)
    1-3.4754 (12)836 (11)1.06 (0.95-1.20)359 (15)444 (15)0.91 (0.77-1.08)345 (10)346 (8)1.21 (1.02-1.44)
    3.5-6.9163 (3)210 (3)0.90 (0.72-1.12)105 (4)120 (4)0.91 (0.69-1.21)48 (1)76 (2)0.81 (0.55-1.17)
    7-13.9129 (2)139 (2)1.08 (0.84-1.39)52 (2)55 (2)1.05 (0.71-1.56)66 (2)74 (2)1.08 (0.76-1.52)
    ≥1482 (1)84 (1)1.12 (0.81-1.53)32 (1)39 (1)0.89 (0.55-1.45)45 (1)39 (1)1.44 (0.92-2.25)
    Ptrend0.550.280.11
1-drink increase1.01 (1.00-1.02)1.01 (0.99-1.02)1.01 (1.00-1.03)
Liquor
    Nondrinkers1,122 (18)1,379 (18)1351 (14)424 (15)1709 (21)876 (21)1
    <12,463 (39)3,132 (41)0.90 (0.83-0.98)1,098 (45)1,371 (47)0.90 (0.79-1.02)1,186 (34)1,529 (37)0.93 (0.83-1.04)
    1-3.4940 (15)1,044 (14)1.00 (0.90-1.12)334 (14)402 (14)0.92 (0.77-1.11)541 (16)582 (14)1.07 (0.92-1.24)
    3.5-6.9154 (2)146 (2)1.14 (0.90-1.44)55 (2)61 (2)0.93 (0.63-1.37)93 (3)75 (2)1.40 (1.02-1.93)
    7-13.9162 (3)175 (2)1.00 (0.80-1.26)37 (2)38 (1)1.00 (0.62-1.60)115 (3)131 (3)0.98 (0.75-1.29)
    ≥1495 (2)73 (1)1.41 (1.03-1.94)18 (1)19 (1)1.10 (0.56-2.13)74 (2)50 (1)1.63 (1.12-2.38)
    Ptrend0.280.370.04
1-drink increase1.02 (1.00-1.03)0.99 (0.97-1.02)1.03 (1.01-1.05)
  • * For the test of the interaction between total alcohol consumption (continuous) and menopausal status P = 0.05.

  • For the test of the interaction between alcohol consumption (continuous) and menopausal status: all alcohol, P = 0.05; wine, P = 0.89; beer, P = 0.89; liquor, P = 0.03.

  • Adjusted for age, state, family history of breast cancer, age at menarche, age at first birth, parity, menopausal status, age at menopause, postmenopausal hormone use, body mass index, education, wine, beer, and liquor consumption.