Table 2.

Univariate and multivariate Cox proportional hazards models for prostate cancer mortality in PHS, 1983-2007

Clinical variable at diagnosisnUnivariate
Multivariate*
Hazard ratio (95% CI)PHazard ratio (95% CI)P
Age at diagnosis, y2981.16 (1.08-1.26)0.00011.15 (1.06-1.24)<0.001
Gleason score [4-6 (ref), 7-10]2983.3 (0.76-14.29)0.112.3 (0.5-10.3)0.26
Log (PSA at diagnosis), per 1-unit increase2573.5 (1.92-6.22)<0.00012.9 (1.46-5.58)0.002
p63 percent, per 1% increase2981.07 (1.04-1.10)<0.00011.06 (1.03-1.09)<0.001
p63 percent, tertiles
    Low991.0 (Reference)1.0
    Medium1004.0 (0.9-18.9)0.082.7 (0.6-13.0)0.21
    High995.9 (1.3-27.5)0.024.8 (1.0-22.9)0.05
    Test for trend0.0280.047
  • * Adjusted for age at diagnosis (continuous), year of diagnosis (continuous), and Gleason at prostatectomy/transurethral resection of the prostate (4-6, 7-10).

  • Test for trend.