Table 2.

TGF-α expression (staining optical density) in the normal-appearing rectal mucosa of incident sporadic colorectal adenoma cases and controls, MAP II

Crypt section*Case (n = 29)Control (n = 31)Prop diff (%)Pdiff§Odds ratio (95% CI)
FC1.18 (0.14)0.78 (0.14)51.20.052.23 (0.98-5.07)
L60%2.12 (0.32)1.01 (0.31)109.90.022.16 (1.11-4.17)
U40%2.31 (0.41)0.98 (0.39)135.70.022.12 (1.03-4.38)
L60%/FC1.66 (0.11)1.34 (0.11)23.90.043.75 (1.01-13.91)
U40%/FC1.81 (0.22)1.40 (0.22)29.20.191.52 (0.80-2.90)
  • NOTE: Batch standardized as individual value divided by batch mean; all estimates adjusted for age and sex.

    Abbreviations: FC, full crypt; L60%, lower 60%; U40%, upper 40%; Prop diff, proportional difference.

  • * Full crypt = average expression throughout entire crypt; lower = sections from base of crypt; upper = sections from crypt apex or mouth; ratios of section-specific expression.

  • Mean staining densities and SEs.

  • Difference between means (cases - controls) divided by mean in controls × 100%.

  • § Difference P value for comparison of means (analysis of covariance).

  • Association between TGF-α expression (as a continuous variable) and adenoma (relative odds of being a case) adjusted for age and sex.