Table 4.

The modification of MBL2 haplotypes on risk of lung cancer due to childhood secondhand smoke

MBL2 HaplotypeNCI-MD study*Mayo Clinic study
Cases n (%)Controls n (%)OR (95% CI)Cases n (%)Controls n (%)OR (95% CI)
Exposed to childhood secondhand smoke
Medium MBL levels181 (63)89 (68)1.00 (reference)79 (81)104 (77)1.00 (reference)
    LYQA
    LYPA
Low MBL levels65 (23)33 (25)0.97 (0.59-1.58)8 (8)28 (21)1.06 (0.68-1.98)
    LXPA
    LYPB
    HYPD
    LYQC
High MBL levels41 (14)8 (6)2.52 (1.13-5.60)11 (11)3 (2)2.78 (1.18-3.85)
    HYPA
No exposure to childhood secondhand smoke
Medium MBL levels38 (63)47 (73)1.00 (reference)56 (76)129 (84)1.00 (reference)
    LYQA
    LYPA
Low MBL levels15 (25)14 (22)0.57 (0.18-1.83)12 (16)20 (13)0.75 (0.40-1.66)
    LXPA
    LYPB
    HYPD
    LYQC
High MBL levels7 (12)3 (5)1.19 (0.18-7.79)6 (8)4 (3)1.05 (0.61-11.53)
    HYPA
  • *Only 285 cases and 130 cases had complete MBL2 genotyping information available because of DNA degradation and since the study is ongoing some study participants were accrued after samples were sent for genotyping.

  • ORs are adjusted for age, gender, smoking status, exposure to adult secondhand smoke, education level, first-degree relative with lung cancer number of cigarettes/day (NCI-MD), number of years smoked (NCI-MD), age at initiation (NCI-MD), and time since quitting (NCI-MD).