Table 2.

Association between smoking status/smoking history at diagnosis and mortality during the follow-up period in a cohort of early stage head and neck cancer patients

SmokingPerson-yearsAll-cause mortality
No. of deathsRR* (95% CI)
Cigarette smoking
    Never smokers (n = 17)7511.0
    Former smokers (n = 111)460182.14 (0.28, 16.47)
    Current smokers (n = 136)568434.91 (0.67, 35.98)
Smoking intensity, cigarettes/d
    1-15 (n = 49)22292.43 (0.30, 19.69)
    16-30 (n = 103)423223.59 (0.48, 27.04)
    >30 (n = 95)382305.33 (0.71, 40.00)
    P-trend0.17
Smoking duration, y
    1-30 (n = 78)347101.95 (0.24, 15.86)
    31-40 (n = 61)256153.59 (0.47, 27.54)
    >40 (n = 108)423365.15 (0.69, 38.47)
    P-trend0.004
Pack-years
    Up to 40 (n = 96)407152.49 (0.33, 19.11)
    41-60 (n = 67)276163.88 (0.50, 30.26)
    >60 (n = 84)344305.39 (0.73, 40.12)
    P-trend0.003
  • *Adjusted for age, sex, educational level, BMI, race, randomization group, beer, wine, and liquor. P-trend refers to the test for a linear dose-response relationship for each measure of tobacco use (smoking intensity, duration, and pack-years separately).

  • Among current and former smokers combined, relative to never smokers.