Table 4.

Associations between tobacco smoking and UADT cancer risk by cancer subsite among never alcohol drinkers

UADTOral cavity and oropharynxHypopharynx and larynx
CasesControlsOR (95% CI)CasesControlsOR (95% CI)CasesControlsOR (95% CI)
Tobacco smoking status
    Never451661.00331661.0051661.00
    Former18521.55 (0.77-3.10)5520.62 (0.21-1.82)125210.32 (2.77-38.47)
    Current55545.15 (2.80-9.45)20542.26 (1.02-5.03)285447.32 (12.05-185.80)
    P0.0010.0320.002
Tobacco smoking intensity (cigarettes/d)
    Never451661.00331661.0051661.00
    >0-1018282.62 (1.26-5.45)8281.49 (0.57-3.89)82816.33 (4.14-64.36)
    11-2029413.49 (1.79-6.80)10411.25 (0.49-3.16)144121.27 (5.63-80.40)
    >2025363.44 (1.64-7.22)7361.60 (0.54-4.73)173621.99 (5.62-86.02)
    Ptrend0.5740.9250.651
Tobacco smoking duration (y)
    Never451661.00331661.0051661.00
    1-2015301.99 (0.88-4.48)6300.92 (0.28-3.00)73011.14 (2.54-48.77)
    21-4031552.76 (1.44-5.30)8550.92 (0.35-2.40)195518.57 (5.07-68.04)
    >4026205.48 (2.50-12.01)11203.30 (1.17-9.32)132030.45 (7.50-123.70)
    Ptrend0.0500.0890.157
Tobacco smoking lifetime (cigarettes/life)
    Never451661.00331661.0051661.00
    >0-50,0008191.70 (0.64-4.49)2190.44 (0.09-2.20)41915.43 (2.91-81.82)
    >50,000-100,0001095.19 (1.80-14.94)694.45 (1.19-16.56)4923.81 (3.96-143.00)
    >100,000-500,00045723.08 (1.72-5.54)16721.41 (0.63-3.12)237217.79 (5.08-62.37)
    >500,0009511.51 (3.19-41.57)151.70 (0.15-19.05)85116.10 (18.74-718.90)
    Ptrend0.0840.4120.138
Tobacco smoking pack-years
    Never451661.00331661.0051661.00
    >0-2024462.15 (1.11-4.17)12461.27 (0.55-2.94)104613.02 (3.40-49.80)
    21-4018372.55 (1.20-5.40)5370.85 (0.26-2.83)83712.84 (3.10-53.18)
    >4030227.75 (3.55-16.93)8222.75 (0.94-8.03)212253.11 (13.13-214.90)
    Ptrend0.0040.2820.010

NOTE: Adjusted for center, education, sex, and age. Results on esophagus and cigar or pipe were not included due to sparse data.