Table 2.

Associations between tobacco smoking and UADT cancer risk by cancer subsite

UADTOral cavity and oropharynxHypopharynx and larynxEsophagus
CasesControlsOR (95% CI)CasesControlsOR (95% CI)CasesControlsOR (95% CI)CasesControlsOR (95% CI)
Tobacco smoking status*
    Never1797121.001097121.00347121.00256321.00
    Former4797412.26 (1.82-2.81)2057411.80 (1.37-2.37)2237414.41 (2.98-6.53)375871.77 (1.00-3.12)
    Current1,3907156.72 (5.45-8.30)6607155.83 (4.50-7.54)56871512.19 (8.29-17.92)855094.17 (2.45-7.10)
Tobacco smoking intensity* (cigarettes/d)
    Never1797121.001097121.00347121.00256321.00
    >0-227442.67 (1.58-4.52)14442.44 (1.27-4.69)9444.04 (1.77-9.24)1330.97 (0.12-7.97)
    3-431492.78 (1.69-4.55)18492.76 (1.51-5.02)8493.23 (1.39-7.49)2432.21 (0.48-10.19)
    5-101723012.21 (1.70-2.87)923011.99 (1.44-2.75)553013.50 (2.20-5.56)212542.16 (1.13-4.13)
    11-208085984.95 (3.99-6.13)3845984.24 (3.26-5.52)3155988.38 (5.68-12.35)674713.59 (2.10-6.14)
    >208224615.91 (4.69-7.45)3524614.85 (3.64-6.47)40046111.28 (7.59-16.77)312932.58 (1.37-4.88)
    Ptrend<0.001<0.001<0.0010.313
Tobacco smoking duration* (y)
    Never1797121.001097121.00347121.00256321.00
    1-201534041.49 (1.15-1.94)804041.31 (0.94-1.83)494042.13 (1.33-3.41)173081.88 (0.95-3.74)
    21-401,0407374.50 (3.64-5.56)4887373.76 (2.90-4.87)4367378.01 (5.46-11.75)655452.70 (1.57-4.64)
    >406693137.67 (6.03-9.75)2933136.81 (5.06-9.16)30331313.38 (8.92-20.09)402414.05 (2.21-7.42)
    Ptrend<0.001<0.001<0.0010.024
Tobacco age at start (y)
    Never1797121.001097121.00347121.00256321.00
    ≥205234233.09 (2.44-3.92)2394233.08 (2.31-4.11)2214235.38 (3.57-8.12)443052.68 (1.49-4.84)
    15-199117562.68 (2.14-3.37)4217562.65 (2.02-3.48)3867564.84 (3.25-7.20)565821.70 (0.94-3.10)
    <154252742.59 (1.96-3.41)1992742.74 (1.98-3.80)1802744.35 (2.79-6.78)222071.64 (0.75-3.60)
    Ptrend0.0940.3330.1470.086
Smoking status and pack-years
    Never1797121.001097121.00347121.00256321.00
    Former (>0-20 pack-years) since ≥20 y802631.26 (0.92-1.72)402631.09 (0.73-1.64)252631.71 (0.99-2.97)132131.98 (0.95-4.11)
    Former (>20 pack-years) since ≥20 y42951.59 (1.03-2.43)19951.49 (0.84-2.63)23953.12 (1.70-5.71)75
    Former (>0-20 pack-years) since <20 y751322.41 (1.72-3.37)401322.13 (1.40-3.25)291324.66 (2.70-8.04)51101.15 (0.40-3.29)
    Former (>20 pack-years) since <20 y2842474.24 (3.27-5.49)1062473.05 (2.19-4.25)1482478.69 (5.70-13.23)191842.63 (1.33-5.21)
    Current (>0-20 pack-years)1732193.53 (2.68-4.66)1022193.42 (2.45-4.78)462194.75 (2.90-7.77)131742.60 (1.21-5.58)
    Current (21-40 pack-years)5272587.89 (6.18-10.07)2572586.65 (4.95-8.93)19725813.80 (9.12-20.89)481886.13 (3.38-11.11)
    Current (>40 pack-years)6882449.93 (7.73-12.77)2982448.46 (6.22-11.50)32524418.32 (12.14-27.63)241473.21 (1.62-6.38)
    Ptrend<0.001<0.001<0.001<0.001

NOTE: Ptrend values were calculated among ever smokers only. Tobacco smoking includes cigarettes, cigar, and pipe in cigarette equivalents.

  • *Adjusted for age, sex, education, center, and alcohol drinking intensity (continuous) and duration (continuous).

  • Adjusted for sex, education, center, alcohol drinking intensity (continuous) and duration (continuous), and pack-years of smoking (continuous).

  • Adjusted for age, sex, education, center, and alcohol drinking intensity (continuous).