Table 2.

Variables that influences CPD, expired CO, or plasma COT levels

VariableCPDExpired CO (ppm)Plasma COT (ng/mL)
MeanSDnPMeanSDnPMeanSDnP
CYP2A6 genotype
    NM7.042.512750.8514.339.242740.13221.74146.312750.002
    IM6.972.567011.946.9070249.17149.0670
    SM7.142.4419713.539.22197272.63*165.17197
3HC/COT ratioPearson's rPPearson's rPPearson's rP
Correlations0.0010.98−0.060.12−0.28<0.001
CategoricalMeanSDnPMeanSDnPMeanSDnP
Fastest—quartile 47.222.501510.9812.959.351510.28189.25127.20151<0.001
Quartile 37.282.4815014.459.72150255.45147.85150
Quartile 27.072.3515114.108.52151265.94146.61151
Slowest—quartile 17.222.4415012.896.88150278.62170.57150
GenderMeanSDnPMeanSDnPMeanSDnP
Males7.042.552330.2713.428.192330.63231.79150.282330.09
Females7.202.3846713.888.98466249.60153.84466
Menthol cigarettesMeanSDnPMeanSDnPMeanSDnv
Yes7.072.465690.0513.498.285690.51242.93150.555680.55
No7.532.3213114.7410.42131246.84162.71131
BMIPearson's rPPearson's rPPearson's rP
Correlations−0.030.39−0.110.0040.003−0.19<0.001
CategoricalMeanSDNPMeanSDNPMeanSDNP
    Low (<30.0)7.352.413810.0214.358.743800.01268.19156.37380<0.001
    High (≥30.0)6.902.4631612.978.70316213.57142.65316
AgePearson's rPPearson's rPPearson's rP
Correlations0.050.21−0.0010.970.040.34
CategoricalMeanSDnPMeanSDnPMeanSDnP
19-296.322.27600.1811.725.68600.95226.17147.88600.42
30-397.202.3614814.149.80148241.29149.26148
40-497.162.4828013.758.54280239.85158.70279
50-597.412.4515813.778.30157255.99151.70158
60-777.042.515214.2910.3152248.82141.6952
Depth of inhalationMeanSDnPMeanSDnPMeanSDnP
Into chest7.312.453830.1314.009.083830.61242.19156.543820.50
Puff/throat only6.962.4331513.398.30315245.78148.78315
Other smokers at homeMeanSDnPMeanSDnPMeanSDnP
Yes7.002.374260.6113.418.284250.79256.01160.084260.19
No7.242.4827413.939.00274235.75147.58273
  • *Denotes statistical significance in plasma COT levels in normal metabolizers vs slow metabolizers.

  • Denotes statistical significance in plasma COT levels in quartile 4 (fastest activity) vs quartile 1 (slowest activity). No significant differences in plasma COT levels were found between intermediate metabolizers vs normal metabolizers or slow metabolizers, or between the other quartiles. Raw data are listed although statistical analyses were done on log-transformed data for CPD, expired CO and plasma COT.