Table 13.

Salmonella strain specificity*

CompoundsTA98TA100TA1535TA1537TA102YG1024
Sequence specificityFrameshift mutationMissense mutationMissense mutationFrameshift mutationMissense mutationFrameshift mutation
Special characteristicsParent strain TA1538, with pKM101 plasmid, ampicillin resistantParent strain TA1535 with pKM101 plasmid, ampicillin resistantAmpicillin resistantAmpicillin resistantpKM101 and pAQ1 plasmids, tetracycline and ampicillin resistantParent strain TA1538, with pKM101 plasmid, ampicillin resistant
Detects DNA cross-linking agents, e.g., formaldehyde and acrolein and ROSO-acetyl transferase-overproducing strain
BaPBenzo(a)pyrenePositive (+/−)Positive (+/−)Positive (+/−)Positive (+/−)N/AN/A
Trace metalsCadmiumNegativeNegativeNegativeNegativeN/AN/A
LeadNegativeNegativeNegativeNegativeN/AN/A
NickelEquivocalEquivocalNegativeN/AN/A
ChromiumPositive (+/−)Positive (+/−)Positive (+/−)N/AN/A
CarbonylsFormaldehydePositive (+)Positive (+)Positive (+/−)Positive (+/−)Positive (+/−)N/A
AcetaldehydeNegativeNegativeNegativeNegativeN/AN/A
Acetaldehyde oximePositive (+/−)Positive (+/−)Positive (+)N/AN/A
CrotonaldehydePositive (+/−)Positive (+/−)Positive (+/−)Positive (+/−)N/AN/A
HumectantsGlycerolEquivocalEquivocalNegativeEquivocalN/AN/A
TSNAsN'-nitrosoanabasine (NAB)N/AN/AN/AN/A
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL/NNA)N/AN/AReactive (284)N/A
N'-nitrosonornicotine (NNN)N/AReactive (285)Reactive (286)N/A
4-(N-methyl-N-nirtosamino)-1-(3-pyridyl)-1-butanone (NNK)N/AN/AReactive (286)N/A
N'-nitrosoanabatine (NAT)N/AN/AN/AN/A
Volatile nitrosaminesN'-nitrosodimethylamine (NDMA)Positive (+)Positive (+/−)Positive (+/−)/Reactive (286)Positive (+/−)N/A
N-nitrosopyrrolidine (NPY)N/APositive (287)Reactive (288)N/A
N-nitrosodiethanolamine (NDELA)Positive (+)Positive (+)Positive (+/−)N/A
NDEA (289)PositivePositive (+/−)Reactive (289)N/A
NMOR (290)Positive (+)Positive (+/−)Reactive (290)N/A
Nitrosopiperidine (NPIP)Positive (−)Positive (+/−)Positive (+)Positive (+/−)N/A
Nitrososarcosine (NSAR)N/AN/AN/AN/A
PAHsPhenanthreneN/AN/AN/AN/A
PyrenePositive (+/−)Positive (+/−)Positive (+/−)Positive (+/−)N/A
NapthaleneN/AN/AN/ANegativeN/A
1-MethylphenanthrenePositive (+)Positive (+/−)N/AN/A
Benzo[k]fluoranthenePositive (+/−)Positive (+/−)N/AN/A
Benzo[b]fluoranthenePositive (+/−)Positive (+/−)N/AN/A
ChryseneN/AN/AN/AN/A
Dibenz(a,h)anthracenePositive (+/−)Positive (+)N/AN/A
Aromatic AminesO-ToluidinePositive (+/−)Positive (+)Positive (+/−)N/AReactive (220, 221, 291)
1-NaphthylaminePositive (+/−)Positive (+/−)N/AN/A
2-AminonapthleneN/A
3-AminobiphenylN/A
4-AminobiphenylPositive (+/−)Positive (+)Positive (+/−)Positive (+/−)N/A
O-AnisidinePositive (+/−)Positive (+/−)NegativeNegativeN/A
ROSReactive (292)N/A
Other ChemicalsNitrateNegativeN/AN/AN/AN/A
3-(Methylnitrosamino)-propionic acid (MNPA)N/AN/AN/AN/AN/A
4-(Methylnitrosamino)-butyric acid (MNBA)N/AN/AN/AN/AN/A
AmmoniaNegativeNegativeNegativeN/AN/A
AnthraceneN/AN/AN/AN/AN/A
ArsenicN/AN/AN/AN/AN/A
UrethanePositive (+/−)Positive (+/−)Positive (+)Positive (+/−)N/AN/A

Abbreviation: ROS, reactive oxygen species; TSNA; PAH, polycyclic aromatic hydrocarbon.