Table 3.

Stratified analysis by age, gender, ionizing radiation exposure history, and histologic type of glioma

VariablesDominant
Recessive
XRCC1 R399Q
PARP1 A762V
MGMT F84L
LIG1 5′UTR
ERCC1 3′UTR
APEX1 E148D
OR (95% CI)*
OR (95% CI)*
OR (95% CI)*
OR (95% CI)*
OR (95% CI)*
OR (95% CI)*
No.GA/AA vs GGNo.TC/CC vs TTNo.CT/TT vs CCNo.CT/TT vs CCNo.GG vs TT/GTNo.TT vs CC/CT
Age (y)
    ≤45142/1431.47 (0.91-2.38)142/1430.62 (0.38-1.06)140/1430.57 (0.32-1.00)142/1430.46 (0.27-0.80)142/1435.88 (1.64-20.0)142/1430.96 (0.57-1.64)
    >45231/2211.39 (0.95-2.03)230/2210.76 (0.52-1.14)230/2200.76 (0.49-1.20)230/2210.85 (0.55-1.29)230/2201.08 (0.52-2.27)230/2200.54 (0.36-0.85)
P for interaction0.860.540.440.0850.0160.11
Gender
Male214/1590.94 (0.62-1.44)213/1590.58 (0.38-0.91)211/1590.53 (0.32-0.88)213/1590.79 (0.50-1.24)214/1571.92 (0.78-4.76)213/1580.70 (0.43-1.14)
Female158/2042.27 (1.45-3.57)158/2050.86 (0.55-1.35)156/2030.86 (0.53-1.40)158/2050.56 (0.34-0.92)156/2041.79 (0.76-4.15)156/2040.67 (0.42-1.10)
P for interaction0.00470.230.190.310.900.91
IR exposure history
No333/3351.37 (1.00-1.89)332/3360.76 (0.55-1.06)329/3350.68 (0.48-1.00)332/3360.71 (0.50-1.01)331/3341.89 (1.00-3.56)331/3340.70 (0.49-1.01)
Yes35/213.45 (1.11-11.1)35/210.20 (0.08-0.62)35/210.76 (0.20-2.94)35/210.26 (0.08-0.91)35/201.32 (0.11-16.7)34/210.40 (0.10-1.54)
P for interaction0.140.0360.820.0720.790.44
Histologic type
High grade213/3631.46 (1.01-2.08)212/3640.79 (0.54-1.15)211/3620.70 (0.46-1.08)212/3640.77 (0.51-1.14)214/3611.97 (1.00-3.95)212/3620.50 (0.32-0.78)
Medium grade76/3631.15 (0.69-1.90)76/3640.52 (0.28-0.95)74/3620.52 (0.26-0.99)76/3640.47 (0.24-0.88)75/3611.77 (0.66-4.71)76/3621.32 (0.75-2.30)
Low grade82/3631.51 (0.91-2.51)82/3640.72 (0.41-1.22)82/3640.75 (0.42-1.35)82/3640.66 (0.38-1.17)80/3611.66 (0.63-4.37)79/3620.91 (0.51-1.63)
  • * Adjusted for age and gender, accordingly.

  • Numbers of cases/controls.