Table 2.

Genotype frequencies of 18 single-nucleotide polymorphisms among cases and controls and their associations with risk for glioma

PathwayGene and SNPGenotypeNo. (frequency)
Logistic regression OR (95% CI)*Bootstrap OR (95% CI)
CasesControls
NER
    DMXPC V499ACC220 (59.9%)206 (56.6%)1.00 (reference)1.00 (reference)
rs2228000CT/TT147 (40.1%)158 (43.4%)0.85 (0.63-1.16)0.87 (0.63-1.18)
XPD R156RGG123 (33.0%)101 (27.7%)1.00 (reference)1.00 (reference)
rs238406GT/TT250 (67.0%)263 (72.3%)0.77 (0.56-1.05)0.78 (0.56-1.05)
XPD Q751KTT139 (37.9%)161 (44.5%)1.00 (reference)1.00 (reference)
rs13181TG/GG228 (62.1%)201 (55.5%)1.30 (0.96-1.75)1.31 (0.97-1.74)
    RMXPC Q939KAA/AC315 (84.9%)297 (81.4%)1.00 (reference)1.00 (reference)
rs2228001CC56 (15.1%)68 (18.6%)0.75 (0.50-1.11)0.76 (0.49-1.10)
XPG H1104DCC/CG353 (94.6%)351 (96.4%)1.00 (reference)1.00 (reference)
rs17655GG20 (5.4%)13 (3.6%)1.47 (0.71-3.05)1.61 (0.69-3.36)
ERCC1 3′UTRGG/GT338 (91.6%)345 (95.3%)1.00 (reference)1.00 (reference)
rs3212986TT31 (8.4%)17 (4.7%)1.86 (1.01-3.46)1.97 (1.01-3.73)
BER
    DMXRCC1 R399QGG149 (39.9%)169 (46.4%)1.00 (reference)1.00 (reference)
rs25487GA/AA224 (60.1%)195 (53.6%)1.43 (1.05-1.92)1.44 (1.06-1.92)
PARP1 A762VTT267 (71.8%)236 (64.7%)1.00 (reference)1.00 (reference)
rs1136410TC/CC105 (28.2%)129 (35.3%)0.71 (0.52-0.97)0.72 (0.52-0.99)
    RMXRCC1 W194RCC/CT209 (99.7%)362 (99.2%)1.00 (reference)1.00 (reference)
rs1799782TT1 (0.3%)3 (0.8%)0.52 (0.07-5.26)N.A
OGG1 C326SCC/CG355 (95.4%)345 (94.5%)1.00 (reference)1.00 (reference)
rs1052133GG17 (4.6%)20 (5.5%)0.85 (0.44-1.65)0.92 (0.40-1.84)
APEX1 E148DCC/CT289 (78.1%)262 (72.2%)1.00 (reference)1.00 (reference)
rs3136819TT81 (21.9%)101 (27.8%)0.68 (0.48-0.97)0.70 (0.50-0.98)
Direct repair
    DMMGMT F84LCC299 (81.0%)267 (73.6%)1.00 (reference)1.00 (reference)
rs12917CT/TT70 (19.0%)96 (26.4%)0.67 (0.45-0.95)0.69 (0.47-0.97)
    RMMGMT V143IAA/AG379 (97.9%)369 (98.8%)1.00 (reference)1.00 (reference)
rs2308321GG8 (2.1%)4 (1.2%)1.95 (0.58-6.84)N.A
MGMT R178KAA/AG364 (97.8%)359 (98.7%)1.00 (reference)1.00 (reference)
rs2308327GG8 (2.2%)4 (1.3%)1.97 (0.57-6.67)N.A
DSBR
    RMXRCC3 T241MCC/CT308 (83.5%)315 (87.5%)1.00 (reference)1.00 (reference)
rs861539TT61 (16.5%)45 (12.5%)1.43 (0.93-2.18)1.46 (0.92-2.23)
NBS Q185EGG/GC341 (91.4%)318 (87.1%)1.00 (reference)1.00 (reference)
rs1805794CC32 (8.6%)47 (12.9%)0.65 (0.40-1.05)0.66 (0.40-1.03)
Others
    DMLIG1 5′UTRCC285 (76.6%)255 (69.9%)1.00 (reference)1.00 (reference)
rs20579CT/TT87 (23.4%)110 (30.1%)0.67 (0.48-0.94)0.68 (0.48-0.92)
    RMLIG1 A170AAA/AC278 (74.7%)281 (77.0%)1.00 (reference)1.00 (reference)
rs20580CC94 (25.3%)84 (23.0%)1.14 (0.81-1.61)1.16 (0.81-1.61)
  • NOTE: The Akaike's information criterion was used to determine the genetic model for each single-nucleotide polymorphism.

    Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; DM, dominant genetic model; RM, recessive genetic model; N.A, not available; NER, nucleotide excision repair; BER, base excision repair; DSBR, DSB repair.

  • * Adjusted for age and gender.

  • Bootstrapping mean odds ratio and its corresponding 95% CI.