Table 1.

Comparison of estrogen metabolism in wild-type and HPV transgenic mice with and without 2,000 ppm DIM in the diet

E1E22-OHE116-OHE14-OHE1E3C-2/C-16 ratio
Wild type, n = 9Mean4.70.80.91.90.01.50.5
SD5.00.51.01.50.11.5
Wild type with DIM, n = 7Mean4.80.23.21.10.00.12.8
SD4.30.23.71.00.00.3
Transgenic, n = 10Mean3.60.30.31.30.00.70.2
SD4.20.30.30.90.00.7
Transgenic with DIM, n = 10Mean1.01.61.00.90.00.91.1
SD1.22.61.11.10.11.0

NOTE: DIM increased C-2 hydroxylation of estradiol in both wild-type mouse and HPV transgenic mouse by 28% (P < 0.05) and 33% (P < 0.05), respectively.