Table 3.

Crude and adjusted RRs of developing breast cancer with 95% CI for quartiles of total testosterone, free testosterone, estradiol, and SHBG in serum of postmenopausal women of the ORDET cohort

Cases/controlsCrude RR (95% CI)Adjusted RR* (95% CI)
Total testosterone (median nmol/L)
    1 (0.48)25/1811.001.00
    2 (0.73)31/1531.50 (0.85-2.66)1.48 (0.83-2.64)
    3 (0.97)45/1482.36 (1.37-4.06)2.39 (1.38-4.13)
    4 (1.34)64/1603.13 (1.86-5.28)3.28 (1.93-5.55)
    P for trend<0.001<0.001
    Continuous1.54 (1.27-1.88)1.58 (1.29-1.93)
Free testosterone (median pmol/L)
    1 (0.66)26/1621.001.00
    2 (1.32)40/1631.55 (0.90-2.69)1.60 (0.92-2.78)
    3 (2.15)38/1621.57 (0.89-2.77)1.56 (0.88-2.78)
    4 (3.68)61/1552.74 (1.60-4.69)2.86 (1.66-4.94)
    P for trend<0.001<0.001
    Continuous1.34 (1.11-1.62)1.36 (1.13-1.65)
Estradiol (median pmol/L)
    1 (8.1)32/1611.001.00
    2 (16.5)47/1601.50 (0.90-2.49)1.47 (0.88-2.44)
    3 (23.5)40/1611.32 (0.77-2.24)1.33 (0.78-2.28)
    4 (36.5)46/1601.46 (0.87-2.46)1.50 (0.88-2.54)
    P for trend0.2670.216
    Continuous1.09 (0.90-1.33)1.09 (0.90-1.33)
SHBG (median nmol/L)
    1 (48.6)47/1611.001.00
    2 (77.4)35/1600.71 (0.42-1.19)0.69 (0.41-1.17)
    3 (102.0)50/1611.00 (0.61-1.63)0.98 (0.59-1.61)
    4 (149.0)33/1600.66 (0.39-1.12)0.66 (0.39-1.13)
    P for trend0.2530.267
    Continuous0.86 (0.70-1.05)0.86 (0.71-1.05)
  • * Adjusted for age at first birth, age at menarche, age at menopause, and family history of breast cancer.

  • P value for trend from model with the median of quartiles entered as continuous variables.

  • Log transformed.