Table 3.

DFS and time to recurrence in patients curatively treated for CRC

RR for second cancer, recurrence, or death of any cause (DFS)RR for recurrence of CRC (time to recurrence)
nUnivariateMultivaritenUnivariateMultivarite
RR (95% CI)RR (95% CI)RR (95% CI)RR (95% CI)
Age at operation, y
    <751541.0 (reference)1.0 (reference)1541.0 (reference)1.0 (reference)
    ≥751231.87 (1.32-2.65)2.23 (1.56-3.18)1230.87 (0.51-1.47)0.80 (0.47-1.38)
Disease stage
    I451.0 (reference)1.0 (reference)451.0 (reference)1.0 (reference)
    II1311.57 (0.85-2.87)1.57 (0.84-2.92)1316.04 (0.80-45.36)4.98 (0.65-38.08)
    III1001.62 (1.20-2.19)1.60 (1.17-2.19)1004.64 (1.72-12.52)4.23 (1.55-11.52)
Differentiation grade
    High-moderate2211.0 (reference)1.0 (reference)2121.0 (reference)1.0 (reference)
    Poor561.30 (0.86-1.96)1.30 (0.85-1.98)561.02 (0.57-1.82)1.03 (0.53-1.98)
Lymphatic or vascular vessel invasion
    No invasion2521.0 (reference)1.0 (reference)2521.0 (reference)1.0 (reference)
    Invasion251.93 (1.15-3.21)1.55 (0.91-2.64)252.17 (1.07-4.42)1.25 (0.60-2.60)
CEA, ng/mL
    <62041.0 (reference)1.0 (reference)2771.0 (reference)1.0 (reference)
    ≥6621.55 (1.06-2.29)1.44 (0.98-2.13)02.21 (1.29-3.77)2.10 (1.22-3.62)
TrpRS score
    1-22081.0 (reference)1.0 (reference)2081.0 (reference)1.0 (reference)
    3650.60 (0.38-0.95)0.59 (0.37-0.95)650.31 (0.13-0.73)0.42 (0.17-1.02)

NOTE: Univariate and multivariate analyses including age, disease stage, differentiation grade, lymphatic or vascular vessel invasion, CEA, and TrpRS score.