Table 1.

Means and ranges of individual and grouped urinary EM), expressed as absolute concentrations (pmol/mg creatinine), percent of the total EM, and selected EM ratios; first collection

EM measureMean (5th-95th percentile)
pmol/mg creatinine% of total
Total EM219 (117-454)
Parent EM44.0 (21.6-84.4)21.11 (11.95-33.86)
    Estrone31.0 (13.7-62.3)14.97 (7.85-25.03)
    Estradiol12.3 (5.40-27.3)6.15 (2.54-12.67)
Catechol EM68.2 (22.9-214)35.36 (11.79-64.57)
2-Catechol EM59.7 (18.1-198)31.22 (10.09-55.34)
    2-Hydroxyestrone53.3 (16.4-179)28.02 (9.18-51.10)
    2-Hydroxyestradiol5.94 (1.80-20.8)3.20 (0.96-6.09)
4-Catechol EM
    4-Hydroxyestrone7.57 (2.24-25.7)4.14 (0.99-8.39)
Methylated catechol EM8.72 (2.91-26.5)4.65 (1.47-9.27)
Methylated 2-catechol EM8.46 (2.76-24.8)4.54 (1.38-9.23)
    2-Methoxyestrone5.93 (1.93-19.7)3.25 (0.86-7.36)
    2-Methoxyestradiol0.79 (0.30-2.14)0.40 (0.17-0.74)
    2-Hydroxyestrone-3-methyl ether1.41 (0.42-4.39)0.80 (0.25-1.55)
Methylated 4-catechol EM0.20 (0.08-0.57)0.11 (0.04-0.24)
    4-Methoxyestrone0.16 (0.06-0.47)0.09 (0.03-0.21)
    4-Methoxyestradiol0.04 (0.01-0.14)0.02 (0.00-0.07)
2-Hydroxylation pathway EM69.6 (22.0-209)35.76 (12.08-61.51)
4-Hydroxylation pathway EM7.85 (2.37-26.2)4.25 (1.11-8.44)
16-Hydroxylation pathway EM76.9 (32.6-184)38.88 (17.16-67.15)
    16α-Hydroxyestrone12.9 (4.70-40.1)7.09 (1.70-14.59)
    Estriol32.6 (11.1-93.2)17.44 (5.68-34.12)
    17-Epiestriol2.19 (0.52-10.5)1.51 (0.24-5.28)
    16-Ketoestradiol18.2 (7.99-43.9)9.21 (3.47-15.57)
    16-Epiestriol7.30 (3.50-16.3)3.65 (1.60-6.33)
Ratios
4-Catechol/2-catechols0.13 (0.06-0.29)
2-Catechols/16-pathway0.78 (0.15-3.38)
Catechols/16-pathway0.89 (0.18-3.96)
4-Pathway/2-pathway0.11 (0.05-0.24)
2-Pathway/16-pathway0.90 (0.19-3.80)
4-Pathway/16-pathway0.10 (0.02-0.46)
2,4-Pathway/16-pathway1.01 (0.21-4.27)
2-Pathway/4,16-pathway0.78 (0.18-2.63)
2-Catechols/methylated 2-catechols7.06 (2.73-18.3)
4-Catechol/methylated 4-catechols36.2 (7.98-146)
Catechols/methylated catechols7.80 (3.06-20.6)
Parent estrogens/estrogen metabolites0.26 (0.14-0.51)

NOTE: Means and ranges are geometric for absolute and ratio measures and arithmetic for percent measures.