Sensitivity and specificity of promoter hypermethylation analysis in distinguish between normal breast and pathological samples
| Gene aberrantly methylated | Sensitivity TP/TP+FN % (95% CI) | Specificity TN/FP+TN % (95% CI) | Positive predictive value (95% CI) | Negative predictive value (95% CI) |
|---|---|---|---|---|
| APC | 53 (45-60) | 91 (88-95) | 96 (93-99) | 29 (22-36) |
| CDH1 | 35 (28-42) | 88 (82-92) | 88 (83-93) | 20 (14-26) |
| CTNNB1 | 22 (16-28) | 91 (87-95) | 92 (88-96) | 24 (18-30) |
| ESR1 | 24 (17-31) | 73 (65-81) | 82 (68-82) | 22 (15-30) |
| TIMP3 | 35 (27-43) | 73 (65-81) | 75 (75-88) | 25 (18-32) |
| GSTPI | 19 (12-26) | 90 (85-95) | 86 (80-92) | 26 (19-34) |
| MGMT | N/A | N/A | N/A | N/A |
| THBS1 | N/A | N/A | N/A | N/A |
| TMS1 | N/A | N/A | N/A | N/A |
| At least one of APC, CDH1 and CTNNB1 | 67 (60-74) | 75 (69-81) | 92 (88-96) | 35 (28-42) |
| At least one of APC, CDH1, CTNNB1, TIMP3, ESR1 and GSTP1 | 69 (62-76) | 47 (40-54) | 87 (82-91) | 23 (17-29) |
Abbreviations: 95% CI, 95% confidence Interval; N/A, not applicable; TP, true positive; FN, false negative, TN, true negative.