Table 4.

Sensitivity and specificity of promoter hypermethylation analysis in distinguish between normal breast and pathological samples

Gene aberrantly methylatedSensitivity TP/TP+FN % (95% CI)Specificity TN/FP+TN % (95% CI)Positive predictive value (95% CI)Negative predictive value (95% CI)
APC53 (45-60)91 (88-95)96 (93-99)29 (22-36)
CDH135 (28-42)88 (82-92)88 (83-93)20 (14-26)
CTNNB122 (16-28)91 (87-95)92 (88-96)24 (18-30)
ESR124 (17-31)73 (65-81)82 (68-82)22 (15-30)
TIMP335 (27-43)73 (65-81)75 (75-88)25 (18-32)
GSTPI19 (12-26)90 (85-95)86 (80-92)26 (19-34)
MGMTN/AN/AN/AN/A
THBS1N/AN/AN/AN/A
TMS1N/AN/AN/AN/A
At least one of APC, CDH1 and CTNNB167 (60-74)75 (69-81)92 (88-96)35 (28-42)
At least one of APC, CDH1, CTNNB1, TIMP3, ESR1 and GSTP169 (62-76)47 (40-54)87 (82-91)23 (17-29)

Abbreviations: 95% CI, 95% confidence Interval; N/A, not applicable; TP, true positive; FN, false negative, TN, true negative.