Table 1.

Among 1,378 oncogenic HPV-infected women enrolled in SUCCEED, univariate analyses (adjusted by age in quintiles) of selected HPV cofactors for CIN3 compared with <CIN2, CIN2 compared with <CIN2, and CIN3 compared with CIN2

CharacteristicsCIN3
CIN2
<CIN2
CIN3 vs <CIN2
CIN2 vs <CIN2
CIN3 vs CIN2
nnnOR (95% CI)OR (95% CI)OR (95% CI)
Race
    White2152305081.00 (Reference)1.00 (Reference)1.00 (Reference)
    Black22391120.46 (0.29-0.75)0.77 (0.52-1.14)0.60 (0.35-1.05)
    Indian1421350.95 (0.50-1.79)1.33 (0.76-2.33)0.71 (0.35-1.44)
    Other1111290.90 (0.44-1.83)0.84 (0.41-1.71)1.07 (0.45-2.52)
Ethnicity
    Hispanic37391361.00 (Reference)1.00 (Reference)1.00 (Reference)
    Non-Hispanic2452736111.47 (1.00-2.18)1.56 (1.06-2.29)0.95 (0.58-1.53)
Income ($)
    ≤5,00053721701.00 (Reference)1.00 (Reference)1.00 (Reference)
    5,001-10,00038421250.98 (0.61-1.57)0.79 (0.51-1.24)1.23 (0.70-2.16)
    10,001-15,00053521141.49 (0.95-2.34)1.08 (0.70-1.65)1.39 (0.82-2.33)
    15,001-20,0002937801.16 (0.69-1.97)1.09 (0.68-1.76)1.07 (0.58-1.94)
    20,001-30,0004146791.67 (1.02-2.71)1.38 (0.87-2.17)1.21 (0.70-2.10)
    30,001-40,0001420401.12 (0.57-2.22)1.18 (0.65-2.16)0.95 (0.44-2.05)
    ≥40,0012117322.11 (1.12-3.96)1.25 (0.66-2.40)1.68 (0.81-3.49)
Marital status
    Single961504021.00 (Reference)1.00 (Reference)1.00 (Reference)
    Married1371232642.17 (1.60-2.94)1.25 (0.94-1.66)1.74 (1.22-2.48)
    Divorced4844962.09 (1.39-3.16)1.23 (0.82-1.84)1.71 (1.05-2.76)
    Widowed62212.56 (2.50-63.19)2.68 (0.37-19.19)4.69 (0.93-23.70)
Insurance
    Employer1423571.00 (Reference)1.00 (Reference)1.00 (Reference)
    Health dept91681702.18 (1.15-4.12)0.99 (0.57-1.74)2.20 (1.05-4.59)
    Medic(are/aid)1001493291.24 (0.66-2.31)1.12 (0.67-1.89)1.10 (0.54-2.25)
    None77761951.61 (0.85-3.05)0.97 (0.56-1.68)1.66 (0.80-3.48)
    Self3391.36 (0.32-5.68)0.83 (0.21-3.33)1.64 (0.29-9.29)
Ever pregnant
    No45922421.00 (Reference)1.00 (Reference)1.00 (Reference)
    Yes2432285262.48 (1.75-3.54)1.14 (0.86-1.52)2.18 (1.46-3.25)
    No. pregnancies
        045922421.00 (Reference)1.00 (Reference)1.00 (Reference)
        166651881.89 (1.24-2.89)0.91 (0.63-1.32)2.08 (1.27-3.40)
        257671472.09 (1.34-3.24)1.20 (0.82-1.75)1.74 (1.05-2.87)
        35150942.92 (1.83-4.65)1.40 (0.92-2.13)2.09 (1.23-3.54)
        43625424.61 (2.67-7.97)1.57 (0.90-2.72)2.94 (1.58-5.49)
        ≥53321533.35 (1.95-5.74)1.04 (0.60-1.82)3.21 (1.67-6.17)
    No. live births
        01521601.00 (Reference)1.00 (Reference)1.00 (Reference)
        174681931.53 (0.82-2.87)1.01 (0.57-1.78)1.52 (0.73-3.19)
        272751591.81 (0.96-3.40)1.35 (0.76-2.38)1.34 (0.64-2.81)
        ≥382631132.90 (1.54-5.47)1.59 (0.89-2.86)1.82 (0.87-3.82)
Years between menarche and first sexual intercourse
    <265541471.00 (Reference)1.00 (Reference)1.00 (Reference)
    2, 3961102350.92 (0.63-1.35)1.27 (0.87-1.87)0.73 (0.46-1.14)
    4, 582902050.91 (0.61-1.33)1.20 (0.80-1.78)0.76 (0.47-1.21)
    ≥638581610.53 (0.34-0.84)0.98 (0.64-1.51)0.54 (0.32-0.94)
Age at sexual debut (y)
    ≤161981914401.00 (Reference)1.00 (Reference)1.00 (Reference)
    1741541240.74 (0.50-1.09)1.00 (0.70-1.44)0.73 (0.47-1.15)
    182132920.51 (0.31-0.84)0.80 (0.52-1.24)0.63 (0.35-1.14)
    19-201523640.52 (0.29-0.94)0.83 (0.50-1.37)0.63 (0.32-1.24)
    ≥21914370.54 (0.26-1.14)0.87 (0.46-1.65)0.62 (0.26-1.47)
Lifetime no. sexual partners
    11516661.00 (Reference)1.00 (Reference)1.00 (Reference)
    2-345691671.19 (0.62-2.27)1.70 (0.92-3.15)0.70 (0.31-1.55)
    4-574771651.97 (1.06-3.68)1.93 (1.05-3.54)1.03 (0.47-2.22)
    6-1079992171.60 (0.86-2.97)1.88 (1.04-3.41)0.85 (0.40-1.83)
    ≥1161491302.07 (1.09-3.91)1.56 (0.82-2.94)1.33 (0.60-2.95)
Oral contraceptive use
    Never31391091.00 (Reference)1.00 (Reference)1.00 (Reference)
    Ever2502716321.39 (0.91-2.13)1.20 (0.81-1.77)1.16 (0.70-1.92)
    Oral contraceptive status
            Current93982821.16 (0.73-1.84)0.97 (0.63-1.50)1.19 (0.69-2.07)
            Former1531723411.58 (1.01-2.46)1.41 (0.94-2.12)1.12 (0.67-1.88)
Smoking status
    Never691273431.00 (Reference)1.00 (Reference)1.00 (Reference)
    Current1741563092.80 (2.04-3.85)1.36 (1.03-1.80)2.05 (1.43-2.96)
    Former37341051.75 (1.11-2.76)0.88 (0.57-1.35)2.00 (1.16-3.47)
Smoking duration (y)
    <10931042721.00 (Reference)1.00 (Reference)1.00 (Reference)
    ≥10115851362.47 (1.76-3.48)1.64 (1.15-2.33)1.51 (1.02-2.25)
Smoking (pack-years)
    <590862521.00 (Reference)1.00 (Reference)1.00 (Reference)
    5 to <1572701021.98 (1.34-2.91)2.01 (1.36-2.97)0.98 (0.63-1.53)
    ≥154029412.73 (1.66-4.49)2.07 (1.21-3.54)1.32 (0.75-2.31)
BMI (kg/m2)
    <204642832.06 (1.34-3.17)1.13 (0.74-1.72)1.82 (1.11-2.99)
    20 to <25861433191.00 (Reference)1.00 (Reference)1.00 (Reference)
    25 to <3069651761.45 (1.01-2.10)0.82 (0.58-1.17)1.77 (1.15-2.72)
    ≥3083661761.75 (1.23-2.49)0.84 (0.59-1.18)2.09 (1.38-3.18)
Papanicolaou test (frequency)
    ≥2 times per year34501391.00 (Reference)1.00 (Reference)1.00 (Reference)
    Every year48471361.44 (0.88-2.38)0.96 (0.61-1.53)1.50 (0.83-2.72)
    Every 2 y1321683751.44 (0.94-2.20)1.25 (0.86-1.81)1.16 (0.71-1.89)
    Every ≥3 y2121581.48 (0.79-2.76)1.01 (0.56-1.82)1.47 (0.70-3.10)