Smoking status | No. of risk alleles | |||||
---|---|---|---|---|---|---|

0 | OR (95% CI) | 1 | OR (95% CI) | 2-4 | OR (95% CI) | |

Never smoker | 47/80^{*} | 1.00 | 61/81 | 1.23 (0.75-2.01) | 33/37^{*} | 1.54 (0.85-2.81) |

Smoker | ||||||

≤33 pack-yrs | 74/116^{*} | 2.07 (1.18-3.62)^{†} | 98/122 | 2.49 (1.46-4.26)^{‡} | 43/40^{*} | 3.39 (1.79-6.43)^{§} |

>33 pack-yrs | 136/106^{*} | 4.36 (2.50-7.60)^{∥} | 154/104 | 5.02 (2.89-8.72)^{∥} | 74/34^{*} | 7.24 (3.84-13.68)^{∥} |

NOTE: ORs (95% CIs) and corresponding *P* values were calculated by logistic regression, with zero variant allele in never-smokers as reference group and adjusted for age and gender. *P* value of 0.94 for the interaction term between genotype and smoking in the multivariate model.