Table 7.

Interaction of TERT haplotype and TNKS1 genotype with tobacco smoking on the risk of lung cancer

Smoking statusNo. of risk alleles
0OR (95% CI)1OR (95% CI)2-4OR (95% CI)
Never smoker47/80*1.0061/811.23 (0.75-2.01)33/37*1.54 (0.85-2.81)
Smoker
    ≤33 pack-yrs74/116*2.07 (1.18-3.62)98/1222.49 (1.46-4.26)43/40*3.39 (1.79-6.43)§
    >33 pack-yrs136/106*4.36 (2.50-7.60)154/1045.02 (2.89-8.72)74/34*7.24 (3.84-13.68)

NOTE: ORs (95% CIs) and corresponding P values were calculated by logistic regression, with zero variant allele in never-smokers as reference group and adjusted for age and gender. P value of 0.94 for the interaction term between genotype and smoking in the multivariate model.

  • *Cases no./controls no.

  • P = 0.02 and corrected P value (Pc) by 10,000 times permutation test = 0.06.

  • P = 0.0008 and Pc = 0.005.

  • §P = 0.0002 and Pc = 0.001.

  • P and Pc < 0.0001.