Table 6.

Stratification analysis of the combined effects of TERT (rs2735940 g.C > T and rs2736098 g.G > A) haplotypes and TNKS1 rs6985140 g.A > G

VariableNo. of risk alleles
Cases (n = 720)Controls (n = 720)Adjusted OR (95% CI)
012-4012-401PPH2-4PPH
Age (y)
    ≤62118 (32.4)162 (44.5)84 (23.1)169 (42.3)164 (41.0)67 (16.8)1.01.42 (1.02-1.98)*0.041.95 (1.29-4.27)*0.06
    >62139 (39.0)151 (42.4)66 (18.5)133 (41.6)143 (44.7)44 (13.8)1.01.05 (0.75-1.47) *0.790.211.43 (0.90-2.27) *0.130.33
Smoking
    Never47 (33.3)61 (43.3)33 (23.4)80 (40.4)81 (40.9)37 (18.7)1.01.26 (0.76-2.08)0.371.53 (0.84-2.80)0.06
    Ever
        ≤33 pys74 (34.4)98 (45.6)43 (20.0)116 (41.7)122 (43.9)40 (14.4)1.01.21 (0.81-1.80)0.350.901.66 (0.98-2.80)0.060.84
        >33 pys136 (37.4)154 (42.3)74 (20.3)106 (43.4)104 (42.6)34 (13.9)1.01.15 (0.81-1.64)0.440.771.68 (1.04-2.72)0.040.81
Histology
    SQ113 (35.3)147 (45.9)60 (18.8)302 (41.9)307 (42.6)111 (15.4)1.01.40 (1.03-1.91)§0.031.71 (1.14-2.57)0.01
    AC97 (35.5)114 (41.8)62 (22.7)302 (41.9)307 (42.6)111 (15.4)1.01.14 (0.83-1.57)§0.430.371.65 (1.11-2.46)§0.010.90
    SM42 (36.5)47 (40.9)26 (22.6)302 (41.9)307 (42.6)111 (15.4)1.01.14 (0.72-1.80)§0.580.471.86 (1.07-3.23)§0.030.81

Abbreviations: PH, test for homogeneity; pys, pack-years of smoking; SQ, squamous cell carcinoma; AC, adenocarcinoma; SM, small cell carcinoma.

  • *Adjusted for gender and pack-years of smoking.

  • Adjusted for age and gender.

  • Twelve large cell carcinoma cases were excluded from analysis.

  • §Adjusted for age, gender, and pack-years of smoking.