Table 5.

Combined effects of TERT haplotypes (rs2735940 g.C > T and rs2736098 g.G > A) and TNKS1 rs6985140 g.A > G on the risk of lung cancer

Number of risk alleles*Cases no. (%)Controls no. (%)Adjusted OR (95% CI)P
0257 (35.7)302 (41.9)1.00
1313 (43.5)307 (42.6)1.23 (0.97-1.56)0.09
2130 (18.1)98 (13.6)1.63 (1.18-2.24)0.003
3, 420 (2.8)13 (1.8)1.98 (0.95-4.12)0.07
Ptrend<0.001
Global P0.02
0257 (35.7)302 (41.9)1.00
1313 (43.5)307 (42.6)1.23 (0.97-1.56)0.09
2-4150 (20.8)111 (15.4)1.67 (1.23-2.27)0.001
Ptrend<0.001
Global P0.01
  • *0, ht1-3/ht1-3 + AA; 1, ht4/ht1-3 + AA, ht1-3/ht1-3 + AG; 2, ht4/ht4 + AA, ht4/ht1-3 +AG, ht1-3/ht1-3 + GG; 3, ht4/ht4 + AG, ht4/ht1-3 + GG; and 4, ht4/ht4 + GG.

  • Corrected P values by 10,000-time permutation test: 0.009.

  • Corrected P values by 10,000-times permutation test: 0.002.