Table 4.

Haplotype distributions of the TERT and TNKS1 SNPs among the cases and controls, and their association with the risk of lung cancer

Gene/haplotypeControls (n = 1,440)All cases (n = 1,440)
No. (%)No. (%)OR (95% CI)*
TERT rs2735940 g.C > T and rs2736098 g.G > A
    ht1, C-G843 (58.5)780 (54.2)1.00
    ht2, C-A37 (2.6)50 (3.5)1.45 (0.92-2.26)
    ht3, T-G167 (11.6)164 (11.4)1.08 (0.85-1.38)
    ht4, T-A393 (27.3)446 (31.0)1.26 (1.06-1.50)
    P value0.05
TNKS1 rs6990097 g.T > C, rs6985140 g.A > G and rs7006985 g.A > G
    ht1, T-A-A290 (20.1)284 (19.7)1.00 (0.83-1.21)
    ht2, T-A-G491 (34.1)504 (35.0)1.00 (0.85-1.17)
    ht3, C-A-A456 (31.7)426 (29.6)0.93 (0.79-1.09)
    ht4, C-G-A145 (10.1)182 (12.6)1.33 (1.05-1.69)
    Others§58 (4.0)44 (3.1)
    P value0.12
  • *ORs, 95% CIs, and their corresponding P values are calculated using unconditional logistic regression analysis, adjusted for age, gender, and pack-years of smoking.

  • P = 0.008 and corrected P value (Pc) by 10,000-time permutation test = 0.02.

  • P = 0.02 and Pc = 0.02.

  • §Two haplotypes that had a frequency <5% were excluded from the analysis.