Gene/haplotype | Controls (n = 1,440) | All cases (n = 1,440) | |
---|---|---|---|

No. (%) | No. (%) | OR (95% CI)^{*} | |

TERT rs2735940 g.C > T and rs2736098 g.G > A | |||

ht1, C-G | 843 (58.5) | 780 (54.2) | 1.00 |

ht2, C-A | 37 (2.6) | 50 (3.5) | 1.45 (0.92-2.26) |

ht3, T-G | 167 (11.6) | 164 (11.4) | 1.08 (0.85-1.38) |

ht4, T-A | 393 (27.3) | 446 (31.0) | 1.26 (1.06-1.50)^{†} |

P value | 0.05 | ||

TNKS1 rs6990097 g.T > C, rs6985140 g.A > G and rs7006985 g.A > G | |||

ht1, T-A-A | 290 (20.1) | 284 (19.7) | 1.00 (0.83-1.21) |

ht2, T-A-G | 491 (34.1) | 504 (35.0) | 1.00 (0.85-1.17) |

ht3, C-A-A | 456 (31.7) | 426 (29.6) | 0.93 (0.79-1.09) |

ht4, C-G-A | 145 (10.1) | 182 (12.6) | 1.33 (1.05-1.69)^{‡} |

Others^{§} | 58 (4.0) | 44 (3.1) | — |

P value | 0.12 |

↵*ORs, 95% CIs, and their corresponding

*P*values are calculated using unconditional logistic regression analysis, adjusted for age, gender, and pack-years of smoking.↵

^{†}*P*= 0.008 and corrected*P*value (*Pc*) by 10,000-time permutation test = 0.02.↵

^{‡}*P*= 0.02 and*Pc*= 0.02.↵

^{§}Two haplotypes that had a frequency <5% were excluded from the analysis.