Table 3.

Genotypes of cases and controls and their association with the risk of lung cancer

GeneGenotypesCases n (%)Controls n (%)P*Minor allele frequencyAdjusted OR (95% CI)P
CasesControlsP*
TERTrs2735940 g.C > T
CC237 (32.9)274 (38.1)0.120.420.390.061.00
CT356 (49.4)332 (46.1)1.29 (1.02-1.63)0.04
TT127 (17.6)114 (15.8)1.35 (0.98-1.85)0.06
CC237 (32.9)274 (38.1)0.041.00
CT+TT483 (67.1)446 (61.9)1.31 (1.04-1.63)0.02
rs2736098 g.G > A
GG311 (43.2)345 (47.9)0.010.340.300.011.00
GA322 (44.7)320 (44.4)1.13 (0.91-1.42)0.28
AA87 (12.1)55 (7.6)1.85 (1.26-2.71)0.002§
GG + GA633 (87.9)665 (92.4)0.0051.00
AA87 (12.1)55 (7.6)1.74 (1.21-2.51)0.003
TRF1rs2975843 g.A > G
AA502 (69.7)509 (70.7)0.840.170.160.801.00
AG195 (27.1)186 (25.8)1.02 (0.80-1.31)0.86
GG23 (3.2)25 (3.5)0.86 (0.47-1.56)0.61
rs2975841 g.T > G
TT342 (47.5)322 (44.7)0.120.320.330.871.00
TG289 (40.1)325 (45.1)0.80 (0.64-1.01)0.06
GG89 (12.4)73 (10.1)1.05 (0.74-1.50)0.79
TNKS1rs6990097 g.T > C
TT221 (30.7)218 (30.3)0.930.450.450.741.00
TC352 (48.9)349 (48.5)1.01 (0.79-1.29)0.96
CC147 (20.4)153 (21.2)1.00 (0.74-1.35)0.97
rs6985140 g.A > G
AA548 (76.1)580 (80.6)0.080.130.100.031.00
AG156 (21.7)131 (18.2)1.31 (1.01-1.71)0.04
GG16 (2.2)9 (1.2)2.05 (0.89-4.73)0.09
AA548 (76.1)580 (80.6)0.041.00
AG + GG172 (23.9)140 (19.4)1.36 (1.06-1.76)0.02
rs7006985 g.A > G
AA277 (38.5)288 (40.0)0.350.380.380.911.00
AG344 (47.8)319 (44.3)1.09 (0.86-1.37)0.49
GG99 (13.7)113 (15.7)0.82 (0.59-1.13)0.23
TRF2rs251796 g.T > C
TT274 (38.1)277 (38.5)0.970.390.380.821.00
TC336 (46.7)336 (46.7)0.99 (0.78-1.24)0.90
CC110 (15.3)107 (14.9)1.02 (0.74-1.41)0.91
RAP1rs1865493 g.G > C
GG471 (65.4)482 (66.9)0.170.190.191.001.00
GC228 (31.7)206 (28.6)1.14 (0.91-1.45)0.25
CC21 (2.9)32 (4.4)0.61 (0.34-1.09)0.09
POT1rs10228682 g.A > G
AA209 (29.0)194 (26.9)0.510.480.500.231.00
AG337 (46.8)335 (46.5)0.90 (0.70-1.16)0.42
GG174 (24.2)191 (26.5)0.84 (0.62-1.12)0.22
  • *Two-sided χ2 test for either genotype distributions or allele frequencies between the cases and controls.

  • ORs, 95% CIs and corresponding P values were calculated by unconditional logistic analysis, adjusted for age, gender and pack-years of smoking.

  • Corrected P values by 10,000-times permutation test: 0.046.

  • §Corrected P values by 10,000-times permutation test: 0.004.

  • Corrected P values by 10,000-times permutation test: 0.009.

  • Corrected P values by 10,000-times permutation test: 0.047.