Table 1.

Arterial disease risks, risk ratios, and adjusted hazard ratios

Tamoxifen treated (n = 8,232), no. of cases (risk %)Tamoxifen untreated (n = 8,057), no. of cases (risk %)Risk ratio (95% CI)Adjusted hazard ratio (95% CI)*
Angina pectoris
    First year18 (0.22)16 (0.20)1.1 (0.56-2.2)1.2 (0.57-2.3)
    First 5 years79 (0.96)104 (1.3)0.74 (0.56-0.99)0.88 (0.65-1.2)
Acute myocardial infarction
    First year10 (0.12)6 (0.07)1.6 (0.59-4.5)1.4 (0.52-4.0)
    First 5 years40 (0.49)40 (0.50)0.98 (0.63-1.5)1.0 (0.67-1.6)
Heart failure
    First year8 (0.10)7 (0.09)1.1 (0.41-3.1)0.88 (0.32-2.4)
    First 5 years40 (0.49)35 (0.43)1.1 (0.71-1.8)1.2 (0.77-1.9)
Stroke
    First year20 (0.24)23 (0.29)0.85 (0.47-1.5)0.81 (0.44-1.5)
    First 5 years84 (1.0)87 (1.1)0.95 (0.70-1.3)1.0 (0.76-1.4)
  • * Adjusted for age group, diabetes, renal disease, hypertension, chronic obstructive pulmonary disease, radiation therapy, and chemotherapy.